连续流动化学在药物合成中的应用  

Continuous flow synthesis in drug synthesis

作　　者：周志旭[1] 柳蓓蓓[1] 孙悦[1] 吴成军[1] 赵金龙[1] 孙铁民[1] 

机构地区：[1]沈阳药科大学创新药物研究与设计教育部重点实验室,沈阳110016

出　　处：《中南药学》2014年第2期135-140,共6页Central South Pharmacy

基　　金：教育部创新团队发展计划和辽宁省高校创新团队支持计划的资助

摘　　要：连续流动化学是近十多年来发展的新技术。因连续流动化学具有安全性极高、传热传质速度快、自动化程度高和可在线监测及纯化等优点,促进了其在有机合成反应中的快速发展。在放热量较大、需高温高压和环境污染大的反应中的优势尤为明显。本文综述了近年来连续流动化学技术在药物合成中的应用,进一步说明了它的优点和重要意义,也展示了连续流动化学技术在药物合成中的广阔前景。Continuous flow synthesis is a new developing technology in the past 10 years. It has advantages of high security, heat and mass transfer speed, high degree of automation and the advantages of online monitoring and purifi-cation, which promote its rapid development in the organic synthesis reaction. The reactions at very high temperatures and pressures can be safely carried out. Continuous flow synthesis technology in the application of drug synthesis in recent years has been reviewed in this paper, which further illustrates its advantages and significance, and also shows the prospect of continuous flow in drug synthesis.

关 键 词：连续流动化学 药物合成 工艺优化 

分 类 号：R914[医药卫生—药物化学]