伐昔洛韦联合龈下刮治和根面平整治疗重度慢性牙周炎的疗效观察  

Valacyclovir as an adjunct to full-mouth scaling and root planing of advanced chronic periodontitis:a randomized clinical trail

作　　者：付永伟[1] 李向新[1] 龚永庆[1] 徐宏志[1] 

机构地区：[1]连云港市第一人民医院口腔科,江苏连云港222002

出　　处：《上海口腔医学》2014年第1期103-106,共4页Shanghai Journal of Stomatology

摘　　要：目的:评价伐昔洛韦联合龈下刮治和根面平整治疗重度慢性牙周炎的临床疗效。方法 :将59例重度慢性牙周炎患者随机分为对照治疗组(n=29)和干预治疗组(n=30)。对所有患者进行口腔卫生指导、龈上洁治和抛光。龈上洁治后1周内,干预治疗组口服伐昔洛韦,对照治疗组口服安慰剂。2组患者均在龈上洁治1周后,于48 h内分2次完成龈下刮治和根面平整。在基线点以及牙周治疗后2、6个月时对所有患者进行牙周检查。采用SPSS17.0软件包对数据进行统计学分析。结果:在基线时,对照治疗组与干预治疗组间牙周指标的差异均无显著性。治疗后2个月和6个月,干预治疗组探诊出血(bleeding on probing,BOP)阳性位点百分比减少值、牙周探诊深度(probing depth,PD)≥4 mm的位点百分比减少值和PD的减少值均显著高于对照治疗组(P<0.05),干预治疗组临床附着水平(clinical attachment level,CAL)的减少值与对照治疗组比较虽有所升高,但差异无显著性。结论:应用伐昔洛韦作为重度慢性牙周炎机械治疗的辅助治疗,可显著提高临床疗效。PURPOSE： The aim of this study was to evaluate the clinical benefit of valacyclovir when performing full- mouth periodontal debridement in patients with advanced chronic periodontitis. METHODS： Fifty-nine patients with advanced chronic periodontitis were randomly assigned into control-treatment group （n=29） and intensive-treatment group （n=30）. All patients were given instructions of basic oral hygiene and a standard cycle of supragingival mechanical scaling and polishing. Patients in the intensive-treatment group received oral valacyclovir for 1 week, while patients in the control-treatment group received placebo. Thereafter, patients in both groups underwent full-mouth intensive removal of subgingival dental plaque biofilms with the use of scaling and root planing within 48 hours. Periodontal parameters were evaluated before treatment and 2 or 6 months after treatment. The data was statistically analyzed using SPSS17.0 software package. RESULTS： No significant difference in clinical parameters was noted before treatment. 2 and 6 months after treatment, the mean percentage reduction of sites with BOP and PD i〉4 mm were significantly higher in the intensive- treatment group than in the control-treatment group （P〈0.05）. Similarly, patients in the intensive-treatment group had higher mean PD reduction than those in the control-treatment group 2 months （P〈0.05） and 6 months after therapy （P〈 0.05）. However, the mean values of CAL reduction were slightly and not significantly higher in the intensive-treatment group than in the control-treatment group after therapy. CONCLUSIONS： It may be concluded that valacyclovir significantly improves clinical results of full-mouth non-surgical periodontal debridement in advanced chronic periodontitis.

关 键 词：牙周炎 伐昔洛韦 抗病毒治疗 随机对照试验 

分 类 号：R781.4[医药卫生—口腔医学]