Livin和Smac在鲍恩病及皮肤鳞状细胞癌中的表达  

The expression and significance of Livin and Smac protein in Bowen's disease and skin squamous cell carcinoma

作　　者：李春霞[1] 魏红军[1] 郜玉玲[1] 史同新[1] 李民[1] 曲才杰[1] 

机构地区：[1]青岛市市立医院,山东青岛266011

出　　处：《中国麻风皮肤病杂志》2014年第2期70-73,共4页China Journal of Leprosy and Skin Diseases

摘　　要：目的:确定Livin和Smac在鲍恩病(BD)及皮肤鳞状细胞癌(SCC)中的表达和意义。方法:应用免疫组化SP法检测35例BD和32例SCC中Livin和Smac的表达,分析二者表达的相关性。结果:Livin表达:BD组高于BD癌旁组织(P<0.001);BD癌旁组织高于正常对照组(P<0.05)。SCC组高于SCC癌旁组织(P<0.001);SCC癌旁组织高于正常对照组(P<0.05)。SCC组高于BD组(P<0.05)。Smac表达:BD组低于BD癌旁组织(P<0.01);BD癌旁组织低于正常对照组(P<0.05);SCC组低于SCC癌旁组织(P<0.001);SCC癌旁组织低于正常对照组(P<0.05);SCC组低于BD组(P<0.05)。Livin和Smac在BD中表达无相关性(P>0.05),在SCC中表达呈负相关(P<0.05)。结论:Livin的过表达和Smac的低表达可能在BD和SCC的发生、发展中起一定作用。Objective： To investigate the expression and significance of Livin and Smac protein in Bowen＇s disease（BD） and skin squamous cell carcinoma （SCC）. Methods： Immmunohistochemical SP method was used to detect the expression of Livin and Smac in 35 cases of BD and 32 cases of SCC. The relationship between the expressions of BD and Smac was analyzed. Results： The expression of Livin was higher in BD group than in adjacent tissue of BD （ P〈0.001 ） and higher in adjacent tissue of BD than in control group （P〈0.05）. The expression of Livin was higher in SCC group than in adjacent tissue of SCC （ P〈0.001 ） and was higher in adjacent tissue of SCC than in control group （P〈0.05）. The expression of Livin was higher in SCC group than in BD group （P〈0.05）. The expression of Smae was lower in BD group than in adjacent tissue of BD （P〈 0.001 ） and lower in adjacent tissue of BD than in control group （P〈0.05）. The expression of Smac was Dower in SCC group than in adjacent tissue of SCC （P〈0.001） and was lower in adjacent tissue of SCC than in control group （P〈0.05）. The expression of Smac was lower in SCC group than in BD group （P〈0.05）. There was no relationship between the expression of Livin and Smac in BD （P〉0.05）. There was a negative relationship between the expression of Livin and Smac in SCC （P〈0.05）. Conclusion： The over-expression of Livin and low expression of Smac may be involved in the occurrence and development of BD and SCC.

关 键 词：鲍恩病 癌 鳞状细胞 LIVIN SMAC 

分 类 号：R739.5[医药卫生—肿瘤]