组织黏合剂对内镜黏膜下剥离术难治性出血的临床疗效  

Clinical efficacy of tissue adhesive on intractable bleeding during endoscopic submucosal dissection

作　　者：马丽黎[1] 练晶晶[1] 周平红[1] 徐美东[1] 姚礼庆[1] 陈世耀[1] 

机构地区：[1]复旦大学附属中山医院内镜中心复旦大学内镜诊疗研究所上海消化内镜诊疗工程技术研究中心,上海200032

出　　处：《中华胃肠外科杂志》2014年第3期272-274,共3页Chinese Journal of Gastrointestinal Surgery

摘　　要：目的研究组织黏合剂对治疗内镜下黏膜剥离术（ESD）中难治性出血及预防迟发性出血的疗效。方法上海复旦大学附属中山医院内镜中心自2006年9月至2013年8月在对9874例胃肠道黏膜或黏膜下肿瘤的患者行ESD治疗中，发生5例难治性出血（0．05％），在其他止血方法无效的情况下，运用注射和喷洒组织黏合剂的方法进行止血，观察其疗效及其并发症。结果5例患者运用组织黏合剂后均止血成功，且未发生迟发性出血及穿孔。内镜随访2个月后，见创面愈合并瘢痕形成。结论组织黏合剂对治疗ESD难治性出血快速、有效并安全。Objective To investigate the efficacy of tissue adhesive on intractable bleeding during endoscopic submucosal dissection （ESD） and delayed bleeding. Methods A total of 9874 patients with gastrointestinal mucosal or submucosal tumors underwent ESD in our center from September 2006 to August 2013 and intractable bleeding occurred during ESD in 5 cases. Under the condition of no effective hemostasis methods, the tissue adhesive injection or spray were used to stop the bleeding. The efficacy and safety were evaluated. Results All the 5 cases were successfully managed by the hemostasis method with tissue adhesive without any adverse event. In follow-up of two months after operation, wound healing and scar formation were observed under endoscopy. Conclusion Tissue adhesive is safe, effective and fast for intractable bleeding during ESD and delayed bleeding.

关 键 词：组织黏合剂 难治性出血 内镜黏膜下剥离术 

分 类 号：R735[医药卫生—肿瘤]