Wnt/β-catenin通路与肝星状细胞的活化、增殖  

Role of Wnt/β-catenin pathway in activation and proliferation of hepatic stellate cells

作　　者：王心蕊[1] 鲁玉辉[1] 

机构地区：[1]福建中医药大学中医学院,福建省福州市350122

出　　处：《世界华人消化杂志》2014年第5期609-614,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81173180/H2704;福建省自然科学基金资助项目;No.2011J01216~~

摘　　要：肝纤维化是指各种致病因子导致肝细胞炎症、坏死,肝脏中胶原蛋白等细胞外基质(extracellular matrix)降解与沉积失衡,进而导致肝脏内结缔组织异常增生的病理状态.在肝纤维化的形成过程中,肝星状细胞为主要效应细胞.肝星状细胞的激活、分泌细胞外基质、过度的细胞外基质的沉积是形成肝纤维化的中心环节.Wnt/β-catenin通路参与器官纤维化的机制并没有被明确,但已有文献报道Wnt信号通路参与到器官纤维化和肝纤维化的过程中.国内外也均有研究证实Wnt/β-catenin通路与肝星状细胞的活化增殖、肝纤维化存在着一定的关系.Liver fibrosis refers to a pathological state in which a variety of pathogenic factors lead to hepatocyte inflammation and necrosis, the imbalance between degradation and deposition of collagen and other extracellular matrix （ECM） molecules, and the abnormal proliferation of liver connective tissue. In the process of the formation of hepatic fibrosis, hepatic stellate cells are the major contributor. Activated hepatic stellate cells secrete extracellular matrix components, and excessive deposition of extracellular matrix is the central event in liver fibrosis. Currently, there have been many articles reporting that the Wnt/β-catenin signaling pathway is involved in organ fibrosis and liver fibrosis, but the underlying mechanism has not been clearly clarified. Some studies have also confirmed that there is a certain relationshipbetween the Wnt/β-catenin pathway and activa- tion of hepatic stellate cells in liver fibrosis.

关 键 词：肝纤维化 肝星状细胞 WNT β-catenin通路 

分 类 号：R575.2[医药卫生—消化系统]