质子泵抑制剂防治化疗引起胃肠道黏膜损伤的研究进展  

Advances in prevention and treatment of chemotherapyinduced gastrointestinal mucositis with proton pump inhibitors

作　　者：谢一嫏 黄其春[1] 

机构地区：[1]广西医科大学附属肿瘤医院临床药学科,广西壮族自治区南宁市530021

出　　处：《世界华人消化杂志》2014年第5期642-647,共6页World Chinese Journal of Digestology

摘　　要：质子泵抑制剂(proton pump inhibitors,PPIs)具有抑制胃酸分泌和保护胃黏膜作用,临床常用于治疗酸相关性疾病.肿瘤化疗引起的胃肠道黏膜损伤,一直受到肿瘤学界的重视,在美国国立癌症综合网络(National Comprehensive Cancer Network,NCCN)与癌症辅助治疗多国协会(Multinational Association of Supportive Care in Cancer,MASCC)临床止吐指南中,PPIs之一的奥美拉唑被推荐用于治疗肿瘤化疗引起的上腹痛症状.目前PPIs的适应症有增加趋势,国内临床上广泛用于防治肿瘤化疗引起的胃肠道黏膜损伤.本文就化疗引起胃肠道黏膜损伤机制、PPIs保护胃肠道黏膜机制及其防治化疗引起胃黏膜损伤的临床应用作一综述.Proton pump inhibitors （PPIs） are potent acid- suppressive medications commonly used for management of acid-related diseases. Over the past decade, gastrointestinal injury following chemotherapy has attracted wide attention from oncologists. Two international clinical practice guidelines, the National Comprehensive Cancer Network （NCCN） and the Multinational Asso- ciation of Supportive Care in Cancer （MASCC） antiemesis guidelines, recommend omeprazole for the treatment of chemotherapy-induced epigastric pain. In recent years, PPIs have been widely used for the prevention and treatment of chemotherapy-induced gastrointestinal mucosi- tis. This paper summarizes the mechanisms by which chemotherapy causes damage to the gastrointestinal tract, the mechanisms underlying the protection afforded by PPIs against gastro-intestinal injury induced by chemotherapy, and their clinical applications.

关 键 词：质子泵抑制剂 化疗引起 胃肠道黏膜损伤 防治 

分 类 号：R572[医药卫生—消化系统]