INPP4B和PTEN蛋白在肝细胞癌中的表达及其意义  

Significance of expression of INPP4B and PTEN in hepatocellular carcinoma

作　　者：张洋洋[1] 李建生[1] 贺德志[1] 蒋冬[1] 

机构地区：[1]郑州大学第一附属医院消化内科河南省高等学校临床医学重点学科开放实验室,河南省郑州市450052

出　　处：《世界华人消化杂志》2014年第5期695-699,共5页World Chinese Journal of Digestology

基　　金：河南省教育厅科学技术研究重点基金资助项目;No.14A320040~~

摘　　要：目的:通过检测肝细胞癌(hepatocellular carcinoma,HCC)患者肝癌、癌旁组织及正常肝组织中Ⅱ型多磷酸肌醇4-磷酸酶(inositol polyphosphate 4-phosphatase typeⅡ,INPP4B)和磷酸酯酶(phosphatase and tensin homolog deleted on chromosome ten,PTEN)的表达情况,结合HCC的临床病理特征,探讨其在HCC发生发展中的作用及意义.方法:应用免疫组织化学方法分别检测74例肝癌组织、对应癌旁组织及30例正常肝脏组织中INPP4B和PTEN的表达情况.结果:(1)肝癌组织中INPP4B和PTEN的表达水平显著低于癌旁组织和正常肝脏组织(均P<0.05);(2)INPP4B和PTEN的表达与HCC患者的性别、年龄、肝硬化病史无关,与分化程度、包膜完整程度相关.INPP4B的表达与肿瘤直径相关,PTEN的表达与肿瘤直径无关;(3)肝癌组织中INPP4B和PTEN的表达呈正相关(r=0.561,P=0.000).结论:INPP4B和PTEN在肝癌组织中的低表达及两者表达呈正相关提示两者可能共同参与了HCC的发生发展.AIM: To investigate the expression of INPP4B and PTEN in hepatocellular carcinoma(HCC) and to analyze their correlation with clinicopathological parameters of HCC patients. METHODS: By immunohistochemistry, the expression of INPP4B and PTEN was detected in 74 HCC tissue, 74 matched tumor-adjacent atypical hyperplasia tissues and 30 normal tissues. Correlations between INPP4B and PTEN expression and clinicopathological parameters were analyzed by statistical analysis. RESULTS: The levels of INPP4B and PTEN ex-pression in HCC were significantly lower than those in histologically normal hepatic tissues(both P < 0.05). INPP4B and PTEN protein expression in HCC was not statistically correlated with age, sex, or cirrhosis background, but was significantly correlated with degree of differentiation and presence of tumor capsule. INPP4B protein expression, not PTEN protein expression, was correlated with tumor size. There was a positive correlation between INPP4B protein expression and PTEN protein expression in HCC(r = 0.561, P = 0.000). CONCLUSION: The low expression of INPP4B and PTEN proteins in HCC and their positive correlation suggest that they are possibly involved in the occurrence and development of HCC.

关 键 词：肝细胞癌 II型多磷酸肌醇4-磷酸酶 磷酸酯酶 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]