基于11C-MET PET-CT与MRI对脑胶质瘤精确放疗GTV勾画的比较研究  

Comparative evaluation of 11C-MET PET-CT and MRI for GTV delineation in precision radiotherapy for gliomas

作　　者：王如[1] 钱立庭[2] 汪世存 刘伟[2] 罗文广[2] 张洪波[2] 李广虎[2] 胡智刚[2] 刘磊[2] 

机构地区：[1]安徽省肿瘤医院放疗科,合肥230001 [2]安徽省立医院放疗科,合肥230001 [3]省立医院PET-CT中心,合肥,230001

出　　处：《中华放射肿瘤学杂志》2014年第2期143-146,共4页Chinese Journal of Radiation Oncology

基　　金：安徽省科技攻关计划项目（07010302202）

摘　　要：目的 探讨11C-MET PET-CT和MRI图像对脑胶质瘤GTV确定的差异.方法 选取6例经病理证实为胶质瘤患者的术前MRI及11C-MET PET-CT图像,分别由我科5位医师在两种图像资料上勾画GTV,比较两者差异.结果 在MRI11C-MET PET-CT上勾画的GTV体积相似（P=0.917）,GTV变异系数也相似（P =0.600）.勾画的GTV重合度最大为73.0％、最小为51.8％.方差分析显示不同勾画者之间在两种图像资料上勾画的GTV相似（P =0.709）,但PET-CT组GTV最大差值为27.66 cm3,而MRI组的为40.37 cm3.结论 MRI与PET-CT显示的肿瘤边界存在差异,不同勾画者勾画的GTV相似,PET-CT组的GTV最大差值较MRI组的小,11C-MET PET-CT显示GTV较为直观.Objective To evaluate the difference between MRI and n C-MET PET-CT for gross tumor volume （GTV） delineation in the precision radiotherapy for gliomas. Methods Six patients with a pathologically confirmed diagnosis of gliomas were selected for target delineation. Five physicians in our department were called to delineate the GTV based on the preoperative MRI and n C-MET PET-CT images of these patients. The GTVs based on the two methods were compared. Results There was no significant difference between the GTVs based on MRI and n C-MET PET-CT （P = 0. 917）, and their coefficients of variation were also similar （ P = 0. 600）. The coincidences of GTVs were different among the patients, with a maximum value of 73.0% and a minimum value of 51.8%. GTV showed no significant difference when defined by different physicians on MRI and PET-CT （P = 0. 709） ; the biggest difference was 27. 66 cm3 on PET-CT and 40. 37 cm3 on MRI. Conclusions The boundaries of gliomas defined on MRI and PET-CT are different. The GTVs delineated by different physicians on MRI and PET-CT are similar, and the biggest difference on PET-CT is smaller than that on MRI, which suggests that 11C-MET PET-CT is a more direct way for displaying GTV.

关 键 词：脑肿瘤 体层摄影术 正电子发射型 11C-蛋氨酸 磁共振成像 大体肿瘤体积勾画 

分 类 号：R739.41[医药卫生—肿瘤] R445.2[医药卫生—临床医学] R730.44