补体系统与肝脏疾病的研究进展  

Research progress of relationship between the complement system and liver disease

作　　者：张帆[1] 张金彦[1] 彭志海[1] 

机构地区：[1]上海交通大学附属第一人民医院普外科,上海200080

出　　处：《胃肠病学和肝病学杂志》2014年第3期357-360,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金(81200328)

摘　　要：补体系统由30余种生物蛋白组成，是体内重要的效应系统。补体的各种固有成分在不同激活物的作用下被顺序活化，通过共同的末端通路形成膜攻击复合物，在许多生理活动中发挥重要的作用。血浆中的补体成分80％～90％在肝脏中合成，肝细胞同时表达多种补体受体。最近的研究表明，补体系统也参与了各种肝脏疾病的发病机制，如慢性病毒性肝炎、自身免疫性肝炎等。本文就补体系统与肝脏疾病的研究进展作一综述。The complement system consists of more than 30 kinds of soluble and membrane proteins. It＇ s an impor- tant effect system in vivo. In the role of different activators, the inherent components of the complement are activated in order. They ultimately format the membrane attack complex with the role of cytolytic effect through the common end of the pathway. The complement system plays an important role in many physiological activities. About 80% ~ 90% of plasma complement components are biosynthesized in the liver, while the hepatocytes express a variety of complement re- ceptors. Recent evidence from several studies suggests that the complement system is also involved in the pathogenesis of a variety of liver disorders including chronic viral hepatitis, autoimmune hepatitis and so on. A review of the research progress is given in this paper concerning the relationship between the complement system and liver disease.

关 键 词：补体系统 慢性肝损伤 急性肝损伤 肝癌 肝硬化 肝炎 肝脏疾病 

分 类 号：R575[医药卫生—消化系统]