MGMT和MMP-7在星形细胞瘤中表达及临床意义  

Expression and the clinical significance of MGMT and MMP-7 in human astrocytoma

作　　者：苏赓[1] 周志宇[2] 李国成 莫秋荣[1] 温伟[1] 

机构地区：[1]广西壮族自治区民族医院病理科,南宁530001 [2]广西壮族自治区民族医院神经外科,南宁530001 [3]广西脑科医院神经外科,柳州545005

出　　处：《重庆医科大学学报》2014年第1期30-34,共5页Journal of Chongqing Medical University

摘　　要：目的:研究星形细胞瘤组织中甲基鸟嘌呤DNA甲基转移酶(methylguanine-DNA methyltransferase,MGMT)和基质金属蛋白酶-7(matrix metalloproteinase-7,MMP-7)基因蛋白的表达和意义。方法:应用免疫组化SP法检测49例星形细胞瘤中MGMT和MMP-7基因蛋白的表达。结果:MGMT、MMP-7蛋白在星形细胞瘤中的表达率分别为55.10%(27/49)和51.02%(25/49),MGMT和MMP-7的表达与星形细胞瘤组织病理分级有关(P<0.05),与其他临床因素无关(P>0.05);MGMT和MMP-7蛋白在星形细胞瘤中的表达率复发组与无复发组有明显差异(P<0.05),MMP-7抗原与MGMT表达呈负相关(rs=-0.488,P<0.01)。结论:MGMT和MMP-7可能共同参与了星形细胞瘤的发生与发展,MGMT的低表达甚至缺失和MMP-7高表达对星形细胞瘤的恶性程度及预后有指导意义。Objective：To investigate the expression and significance of methylguanine-DNA methyltransferase （MGMT）and matrix metalloproteinase-7 （MMP-7） protein in human astrocytoma. Methods：Protein expression of MGMT and MMP-7 was detected in 49 cases of human astrocytoma with SP immunohistochemical method. Results：Expression rate of MGMT was 55.10% （27/49） and those of MMP-7 was 51.02 % （25/49）. Expression of MGMT and MMP-7 protein was related with histological grade （P〈0.05）, but not re- lated with other clinical factors（P〉0.05）. There was significant differences in the MGMT and MMP-7 expression rate between group with recurrence and group without recurrence（P〈0.05）. There were significant negative correlations between MGMT and MMP-7 protein expression（rs=-0.488,P〈0.01）. Conclusions：MGMT and MMP-7 play important roles in occurrence and development of human astrocytoma. Low expression of MGMT and over expression of MMP-7 provide important implications of malignancy and prognosis for human astrocytoma.

关 键 词：星形细胞瘤 甲基鸟嘌呤DNA甲基转移酶 基质金属蛋白酶-7 免疫组织化学 

分 类 号：R739.4[医药卫生—肿瘤]