CAR在具有细支气管肺泡癌特征肺癌中的表达及意义  

Coxsackie-virus and adenovirus receptor expression in lung cancer bronchiole-alveolar carcinoma features and its significance

作　　者：郭燕[1] 张军[2] 李海欣[1] 战忠利 

机构地区：[1]天津医科大学肿瘤医院肿瘤组织库,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,天津市300060 [2]天津医科大学总医院心胸外科,天津市300060 [3]天津医科大学总医院病理科,天津市300060

出　　处：《中国肿瘤临床》2014年第5期296-299,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨柯萨奇病毒-腺病毒受体(CAR)在肺腺癌部分亚型中的表达及其与临床病理和患者预后的关系。方法:采用EnVision免疫组化二步法检测CAR在137例具有细支气管肺泡癌特征的肺癌(PWBF)组织中的表达,分析其与临床因素的相关性;并收集患者的生存资料,采用Kaplan-Meier曲线描述生存率,行Log-rank检验。结果:CAR在PWBF、其他类型肺癌及正常组织中的阳性率分别为71.5%、50.0%、13.3%,其差异具有统计学意义;CAR蛋白的表达与病理分型和组织学分级相关,与性别、年龄、临床分期等无关。CAR阳性表达患者的生存时间较阴性者长,但无统计学差异。结论:CAR的表达与肺癌的发生发展相关,并同肺腺癌部分亚型(PWBF)的关系密切。CAR在PWBF中的较高表达为以腺病毒(Ad)载体的基因治疗开辟了更为广阔的空间;同时CAR的高度可调节性也为肺癌其他类型的基因治疗提供了可靠的依据和美好的前景。Objective： This study aims to investigate the protein expression of coxsackle-virus and adenovlrus receptor （CAR） m partial subtypes of pulmonary adeno-carcinoma, as well as its expression with clinico-pathological factors and prognosis. Methods： CAR expression was immunohistochemicaUy assessed in 137 cases of lung cancer with bronchiole-alveolar carcinoma （PWBF） fea- tures, and analyzed in relation to various clinico-pathological parameters. All data were analyzed using SPSS statistics software, and Ka- plan-Meier survival curves were constructed. A Log-rank test was also conducted. Results： The CAR positive rates in PWBF, other types of lung cancer, and normal lung tissue were 71.5%, 50.0%, and 13.3%, respectively. The difference was statistically significant （P〈0.05）. In addition, a statistically significant difference was observed between the positive expression of CAR and other clini- co-pathologic parameters, such as pathological type and histological differentiation. No statistical significance was observed in other pa-rameters, such as gender, age, smoking, and tumor diameter. Patients with CAR positivity were characterized by longer survival times than the others; however, this difference did not reach statistical significance. Conclusion： CAR is related to the occurrence and devel-opment of lung cancer, especially PWBF. The higher expression of CAR in PWBF for gene therapy with adenovirus vectors opened a broader space. The conspicuous regulation of CAR may be reliable evidence and may bright future for the gene therapy of other types of lung cancer.

关 键 词：柯萨奇病毒-腺病毒受体 肺癌 细支气管肺泡 

分 类 号：R734.2[医药卫生—肿瘤]