酒精性肝病的发病机理和新的治疗靶点  

Pathogenesis and novel therapeutic targets of alcoholic liver disease

作　　者：常彬霞[1,2] 王华[2,3] 邹正升[1] 李保森[1] 高斌[2] 

机构地区：[1]解放军第302医院非感染性肝病诊疗中心,北京100039 [2]美国国立卫生研究院酒精滥用与成瘾研究所(NIH/NIAAA) [3]安徽医科大学肝病研究所,合肥230032

出　　处：《临床肝胆病杂志》2014年第2期113-117,共5页Journal of Clinical Hepatology

摘　　要：酒精性肝病是世界范围内慢性肝病的一个主要原因,但是其发病机制尚不完全清楚,因此缺少靶向治疗的方法。总结了最近一些阐述酒精性肝病发病机制和诊断的研究,并且讨论了酒精性肝炎的几个新的治疗靶点。认为迫切须要将这些靶点转化为酒精性肝病患者的治疗方法。Alcoholic liver disease （ALD） is a leading cause of chronic liver disease worldwide; however, the pathogenesis of ALD is not fully understood and there are no targeted therapies for ALD. In this review article, we summarize the findings from recent studies that have characterized the pathogenesis and diagnosis of ALD. Several novel therapeutic targets for alcoholic hepatitis are also discussed. There is an urgent need to translate these targets into therapies for patients with ALD.

关 键 词：肝疾病 酒精性 发病机制 治疗靶点 综述 

分 类 号：R575.5[医药卫生—消化系统]