SBP1和Caspase-3在人乳腺癌组织中的表达及意义  

Expression and significance of SBP1 and Caspase-3 in human breast cancer

作　　者：伍思琪[1] 张玉英[1] 谭亮[2] 李艳萍[1] 贾琴[1] 吴爽[1] 

机构地区：[1]广东药学院组织学与胚胎学教研室,广东广州510006 [2]韶关学院医学院,广东韶关512026

出　　处：《解剖学研究》2014年第1期39-42,共4页Anatomy Research

基　　金：广东省科技计划项目(2012B031800311)

摘　　要：目的观察人乳腺癌组织中硒结合蛋白1(SBP1)和凋亡调节蛋白(Caspase-3)的表达,探讨SBP1和Caspase-3在乳腺癌发生、发展过程中的作用及其相互关系。方法用免疫组织化学ABC法检测乳腺癌中SBP1和Caspase-3的表达水平,并与癌旁相对正常组织、乳腺良性病变组织进行比较分析。结果 SBP1、Caspase-3在癌旁相对正常乳腺组织中的阳性表达率为100%、86.6%;在乳腺良性病变组织的阳性表达率为93.3%、73.3%;在乳腺癌组织的阳性表达率为82.1%、57.1%。乳腺癌组织中SBP1和Caspase-3的表达水平均明显低于癌旁相对正常组织和乳腺良性病变组织。乳腺癌组织中SBPl与Caspase-3的表达呈正相关。结论乳腺癌组织中SBP1和Caspase-3的表达下调,提示SBPl可能通过促进肿瘤细胞的凋亡来抑制肿瘤的增殖,为进一步对硒诱导SBP1治疗乳腺癌的作用研究提供基础。Objective To investigate the relationship of the expression of SBP1 and Caspase-3 in human breast cancer. Methods The human breast cancer tissues, para-carcinoma breast tissues and breast benign lesions were collected, the expres- sion of SBP1 and Caspase-3 in tissues were detected by immunohistochemistry, and the correlation between SBP1 and Caspase-3 were assessed by statistical approach. Results The expression rate of SBP1 and Caspase-3 were 100% and 86.6% in para- carcinoma breast tissues, 93.3% and 73.3% in breast benign lesions, 82.1% and 57.1% in breast cancer tissues, respectively. Expression rate of SBP1 and Caspase-3 in breast cancer tissues was significantly lower than that in para- carcinoma breast tis- sues and breast benign lesions （P〈0.05）. SBP1 and Caspase-3 expressions were positively correlated（P〈0.05）. Conclusion Down-regulation of SBP1 and Caspase-3 in breast cancer tissues suggest that SBP1 may inhibit tumor growth by promoting apop- tosis of tumor ceils, which may provide a basis for future studies to use selenium to treat breast cancer.

关 键 词：硒结合蛋白1 调亡调节蛋白3 乳腺癌 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]