银耳孢糖组分对^(137)Cs γ射线照射小鼠骨髓细胞染色体畸变及微核率的影响  

Influence of Tremella Fuciformis Berk Spores Polysaccharide A- BTF to Chromosome Aberration and Micronucleus Rate of Marrow Cells in Mice Irradiated by ^(137)Cs γ- ray

作　　者：闫玉军[1] 徐文清[1] 沈秀[1] 王德芝[1] 赵云庭[1] 周则卫[1] 

机构地区：[1]中国医学科学院北京协和医学院放射医学研究所,天津300192

出　　处：《中国辐射卫生》2014年第1期54-56,共3页Chinese Journal of Radiological Health

摘　　要：目的研究银耳孢子发酵物提取的均一体多糖组分A-BTF对γ射线照射诱发的小鼠骨髓细胞染色体畸变和骨髓嗜多染红细胞微核率的影响。方法实验组照射前24 h腹腔注射银耳孢糖组分,对照组腹腔注射生理盐水,小鼠接受137Csγ射线照射后进行小鼠骨髓细胞染色体畸变及骨髓多染红细胞微核率观察。结果银耳孢糖组分ABTF实验组小鼠的染色体畸变率和微核率明显低于对照组,差异具有统计学意义(P<0.01)。结论实验结果表明该均一体银耳孢糖组分A-BTF对γ射线辐射所致小鼠骨髓细胞损伤有明显的防护作用。Objective To study the influence of a homogeneity polysaccharide A--BTF extracted from tremella fnciformis berk spores to chromosome aberration in cells of bone marrow of mice and micronucleus rate of polychromatic erythrocyte in- duced by 137 Cs γ ray irradiation, nehtods Extracted polysaccharide of tremella fuciformis berk spores was administered by intra - abdominal injection at 24 hours before irradiation, and control mice were given physiological saline. The mice were irra- diated by 137 Cs γ- ray, then observed on chromosome aberration of bone marrow cells and micronucleus rate of polychromatic erythrocyte. Results The results show that occurrence of chromosome aberration and micronucleus rate was obviously lower in mice administered prevention with polysaccharide than that of simply irradiated control mice, and with quite significant diffe- rece （P 〈 0. 01 ）. Conclusion It manifests that the homogeneity polysaccharide from tremella fuciformis berk spores is of marked protective effects for damages of bone marrow ceils by irradiation.

关 键 词：银耳孢糖 辐射防护 染色体畸变 微核率 

分 类 号：Q691.9[生物学—生物物理学]