载脂蛋白E基因多态性与中国人群迟发性阿尔茨海默病相关性的Meta分析  

Correlation between genetic polymorphism of apolipoprotein E and late-onset Alzheimer's disease in Chinese population: a Meta-analysis

作　　者：任昌菊[1] 翁鸿 程朝晖[1] 张超[2] 艾志兵 

机构地区：[1]湖北医药学院附属太和医院神经内科,十堰442000 [2]湖北医药学院附属太和医院循证医学中心 [3]上海市浦东新区周浦医院神经内科

出　　处：《中国循证心血管医学杂志》2014年第1期20-24,共5页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的：系统评价载脂蛋白E（ApoE）基因多态性与中国人群迟发性阿尔茨海默病（LOAD）的相关性。方法计算机检索PubMed、EMbase、CBM、CNKI、WanFang Data和VIP数据库，查找ApoE基因多态性与中国人群LOAD相关性的病例-对照研究，检索时限均为建库至2013年8月12日。由两位研究者进行文献筛选、提取资料，并按照NOS工具进行质量评价后，采用Stata 12.0软件进行Meta分析。结果最终纳入9个病例-对照研究，包括732例LOAD患者，1183例健康对照人群。Meta分析结果显示：基因型ε4/4人群LOAD发病风险是基因型ε3/3人群的16.02倍（OR=16.02，95%CI：7.08～36.27，P＜0.001）；基因型ε3/4人群发病风险是基因型ε3/3人群的3.19倍（OR=3.19，95%CI：2.09～4.87，P＜0.001）；基因型ε2/4人群发病风险是基因型ε3/3人群的3.61倍（OR=3.61，95%CI：1.92～6.79，P＜0.001）；等位基因ε4人群发病风险高于等位基因ε3人群3.71倍（OR=3.71，95%CI：2.49～5.52，P＜0.001）；基因型ε2/3、ε2/2及等位基因ε2人群的发病风险无统计学差异。结论当前证据表明，对于中国人群， ApoE等位基因ε4与LOAD发病有关，且基因型ε4/4是LOAD的高危险因素；等位基因ε2与LOAD发病无相关性。Objective To review systematically the correlation between genetic polymorphism of apolipoprotein E （ApoE） and late-onset Alzheimer’s disease （LOAD） in Chinese population. Methods The databases of PubMed, EMbase, CBM, CNKI, WanFang Database and VIP Database were retrieved with computer for collecting the case-controlled studies about the correlation between genetic polymorphism of ApoE and LOAD in Chinese population from database establishing time to Aug. 12, 2013. The data was selected and extracted by two researches, reviewed according to NOS tool and given a Meta-analysis by using Stata 12.0 software. Results There were totally 9 case-controlled studies included involving 732 LOAD patients and 1183 health control people. Meta-analysis showed that the LOAD risk increased by 16.02 times in population with genotypeε4/4 compared those with genotypeε3/3 （OR=16.02, 95%CI：7.08~36.27, P〈0.001）, by 3.19 times in those with genotypeε3/4 compared with those with genotypeε3/3 （OR=3.19, 95%CI：2.09~4.87, P〈0.001）, by 3.61 times in those with genotypeε2/4 compared with those with genotypeε3/3 （OR=3.61, 95%CI：1.92~6.79, P〈0.001）, by 3.71 times in those with alleleε4 compared with those with alleleε3 （OR=3.71, 95%CI：2.49~5.52, P〈0.001）, and had no statistical difference in those with genotypeε2/3, genotypeε2/2 and alleleε2. Conclusion The current evidence indicates that alleleε4 of ApoE is correlated to LOAD, genotypeε4/4 is a high risk factor and alleleε2 is not correlated to LOAD.

关 键 词：载脂蛋白E 基因多态性 迟发性阿尔茨海默病 META分析 

分 类 号：R749.1[医药卫生—神经病学与精神病学]