吸烟与胰腺癌发生风险的病例对照研究  

Cigarette Smoking and The Risk of Pancreatic Cancer : A Case-control Study

作　　者：阴蒙蒙 马臣 刘曙正[3] 全培良[3] 张萌[3] 陈万青 郑荣寿 张思维 孙喜斌[3] 

机构地区：[1]郑州大学公共卫生学院流行病学教研室,河南郑州450000 [2]重庆市南川区人民医院,重庆408400 [3]河南省肿瘤医院肿瘤防治办公室,河南郑州450008 [4]全国肿瘤防治研究办公室,北京100021

出　　处：《中国肿瘤》2014年第3期200-204,共5页China Cancer

摘　　要：[目的]探讨吸烟与胰腺癌发生风险的关系。[方法]采用1：1配对病例对照研究，病例来源于2011年11月至2013年2月间河南省肿瘤医院住院治疗的新发胰腺癌病例，选取非胰腺癌患者家属为对照组，对病例组和对照组进行问卷调查。采用单因素和多因素条件Logistic回归进行数据分析。[结果]吸烟（OR=2．57，95％CI：1．07～6．16）、清晨吸烟（OR=5．50，95％CI：1．22～24．81）是胰腺癌的危险因素。调整BMI、糖尿病、胆囊疾病等混杂因素后，吸烟、清晨吸烟的相对危险度分别为3．53（95％CI：1．30—9．60），13．14（95％CI：1．45～118．68）：吸烟年限、每天吸烟支数和吸烟指数与胰腺癌发生风险增大存在趋势关系（P趋势〈0．05）。[结论]吸烟、尤其是清晨吸烟是胰腺癌的危险因素，控制烟草是预防胰腺癌的重要措施。[Purpose] To investigate the relationship between smoking and pancreatic cancer. [ Methods ] A pair matched case-control study was carried out. New cases of pancreatic cancer were consecutively recruited at Henan Cancer Hospital from November 2011 to February 2013. Matched controls were selected from the family members of non-pancreatic cancer patients. Information was collected by questionnaire. Univariate and multivariate conditional Logistic regression were performed to data analysis. [ Results ] Smoking （0R=2.57,95% CI ： 1.07-6.16） and smoking in the early morning （0R=5.50,95%CI： 1.22-24.81） were risk factors of pancreatic cancer. After adjusted for BMI,diabetes mellitus,gallbladder disease,the odds ratio of smoking and smoking in the early morning were 3.5（95%CI： 1.3-9.8）, 13.0（95%CI： 1.4-124.5） ,respectively. With the increasing of smoking duration, the number of cigarettes per day and smoking index, significant trends were found between these indicators and pancreatic cancer（Ptrend 〈0.05）. [Conclusion] Smoking,especially smoking in the early morning are the risk factors of pancreatic cancer. Tobacco control is an important measure for the prevention of pancreatic cancer.

关 键 词：胰腺癌 吸烟 配对病例对照研究 条件LOGISTIC回归 

分 类 号：R735.9[医药卫生—肿瘤]