吡啶并[2,3-d]嘧啶衍生物受体的合成及对阴离子识别研究  

Synthesis of Receptors Based on Pyridio[2,3-d]pyrimidines and Their Anion Recognition

作　　者：黄志斌[1] 刘学成[1] 胡明华[1] 林伟[1] 史达清[1] 

机构地区：[1]苏州大学材料与化学化工学部江苏省有机合成重点实验室,苏州215123

出　　处：《有机化学》2014年第2期382-386,共5页Chinese Journal of Organic Chemistry

基　　金：江苏省高校自然科学基金(No.11KJB150014)资助项目~~

摘　　要：通过6-氨基嘧啶、取代苯甲醛与丙二腈的三组分反应合成了4种吡啶并[2,3-d]嘧啶受体分子,利用紫外-可见吸收光谱考察了其与F-,Cl-,Br-,AcO-,4HSO-,2 4H PO-等阴离子的作用.结果表明该类受体分子与阴离子形成氢键配合物,导致吡啶并[2,3-d]嘧啶受体的光谱发生变化.测定了配合物的结合比和稳定常数,发现受体化合物对AcO-离子具有良好的选择性,对其它多种阴离子无影响.Job曲线表明受体分子与阴离子间形成1∶1型的配合物.1H NMR滴定进一步证实了氢键作用的存在及参与类型.Four new receptors containing pyridio[2,3-d]pyrimidines were synthesized via three-component reaction of 6-aminopyrimidine, substituted benzaldehydes and malononitrile. The properties of the receptors with anions such as F-, CI-, Br-, AcO-, HSO4- and H2PO4- were examined by UV-Vis spectroscopy. The results showed that receptors have good selectivity to AcO-. However, no obvious changes were observed on the other anions. The Job plot indicated that a 1 ： 1 stoichiometry complex was formed between receptors and anions. The results also showed that hydrogen-bonding interaction was formed between the receptors and anions. The combination assumed above was confirmed by the results of 1H NMR titration.

关 键 词：吡啶并[2 3-d]嘧啶 阴离子识别 氢键作用 

分 类 号：O641.4[理学—物理化学]