免疫吸附疗法治疗神经系统免疫性疾病的临床效果观察  

Clinical curative effect observation of immunoadsorption in treatment of neurological autoimmune diseases

作　　者：路屹[1] 马博[1] 路宁[2] 

机构地区：[1]蚌埠医学院第一附属医院神经内科,蚌埠233004 [2]安徽省淮南市第一人民医院功能科

出　　处：《南通大学学报（医学版）》2014年第1期50-52,共3页Journal of Nantong University(Medical sciences)

摘　　要：目的:观察免疫吸附疗法(immunoadsorption,IA)治疗神经系统免疫性疾病的临床疗效和不良反应。方法:将神经系统免疫性疾病,随机分为观察组19例和对照组19例。在常规治疗的基础上观察组采用IA治疗,对照组采用传统治疗。观察治疗前后两组患者神经功能缺损恢复情况、疗效、不良反应、免疫球蛋白IgG、IgA、IgM,补体C3、补体C4、血浆总蛋白(serum total protein,STP)含量、血细胞计数的变化。结果:两组治疗均有疗效(P>0.05)。两组治疗后(除对照组IgE外)免疫球蛋白的含量均有降低(P>0.05),观察组IgG的含量较治疗前明显降低,差异有统计学意义(P<0.01)。两组治疗前后血细胞计数无变化。结论:IA可以明显改善患者的临床症状,可能是通过降低血液中IgG的水平而起作用。Objective：To observe the effects and complications of immunoadsorption（IA） therapy on neurological autoimmune diseases. Methods：38 cases with neurological autoimmune diseases were divided into two groups , 19 cases were in treatment group,19 cases were in control group, 19 cases were given IA, others were given traditional therapy in addition to conventional therapy. The change of neurologic impairment, curative effect, adverse reaction, blood cell count, serum immunoglobulins of IgG, IgA, IgM, complement C3,C4 and blood plasma total protein were observed before and after therapy . Results： Clinical symptom of all patients improved after IA therapy and conventional therapy （ P＆gt;0 . 05 ） . Serum immunoglobulins of IgG decreased significantly after adsorption （ P＆lt;0 . 01 ） . Other serum immunoglobulins decreased also , except serum immunoglobulins of IgE in control group（P＆gt;0.05）. Blood cell count hadn’t changed during the whole process. Conclusion：IA in treating neurological autoimmune diseases can obviously improve the symptom of patients , which may play a role by decreasing the level of IgG.

关 键 词：神经系统免疫性疾病 免疫吸附 临床疗效 

分 类 号：R745[医药卫生—神经病学与精神病学]