外胚间充质干细胞在牙组织工程的应用与基因调控  

Research Progress of TGF-β1/CTGF Signal Pathway in Osteoblast and its Effect on Bone Wound Healing

作　　者：吴丽娜[1,2,3] 温秀杰[3] 刘鲁川[3] 行勇军[3] 刘锐[3] 邓蔓菁[3] 聂鑫[1,2] 

机构地区：[1]重庆市沙坪坝区陈家桥医院 [2]第三军医大学大坪医院 野战外科研究所颌面外科,重庆400042 [3]第三军医大学大坪医院 野战外科研究所口腔科,重庆400042

出　　处：《现代生物医学进展》2014年第8期1595-1597,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(31070863)

摘　　要：用干细胞构建组织工程化牙齿是近年来口腔医学领域的研究热点,外胚间充质干细胞是目前已知牙源性干细胞的共同前体细胞,细胞的生物学特性和成牙信号分子环境是牙齿发育与再生的核心与关键,并贯穿于牙齿形成的全过程,是研究牙组织工程最具潜力的种子细胞,明确外胚间充质干细胞成牙分化能力及相关表型特征和分化特性,对进一步深入认识牙齿发育与再生机理具有重要作用。Construction of tissue engineering teeth using stem cells has become one of hotspots in the field of stomatology in re- cent years. Ectomesenchymal stem cells （ESCs） are the common precursor cells of known dental stem cell. Moreover, biological charac- teristics and signaling molecules of ESCs act as core and key in the teeth development and regeneration, and involve in the whole process of the formation of teeth. The ESCs were thought as the most potential seed cells in the dental tissue engineering, therefore, it is important to clarify the charactoristic of ESCs on the dental differentation and to further in-depth study on the dental tissue engineering and regener- ation.

关 键 词：外胚间充质干细胞 成牙分化 基因调控 

分 类 号：Q553[生物学—生物化学]