263例功能性肠病5年随访分析  

Five years follow-up of 263 cases of functional bowel disorders

作　　者：葛建新[1] 印睿[1] 汤玉蓉[1] 黄晓丽[1] 滕晓琨[1] 王平[1] 王国品[1] 

机构地区：[1]东南大学医学院附属南京江北人民医院消化内科,江苏南京210029

出　　处：《中国内镜杂志》2013年第12期1257-1262,共6页China Journal of Endoscopy

基　　金：东南大学医学院江苏省分子和功能影像重点实验室开放研究基金(No.PYZX 2011016);南京市医学科技发展项目(No.YKK11199)

摘　　要：目的随访分析功能性肠病（FBD）患者的生存状态和肠道器质性疾病的发病情况,以初步探讨FBD与患者死亡率和肠道器质性疾病发生率的可能关系。方法连续收集2005年1月~2006年12月于该消化科就诊、18岁以上且以肠道症状为主的患者。以FBD的罗马Ⅲ诊断标准对这些患者进行回顾性诊断,对符合诊断的患者进行5年后随访。随访方式为电话随访和（或）门诊复查;随访内容为患者的生存状态和肠道器质性疾病的发生情况。结果有效随访了263例FBD患者（失访率15.7%）。随访时5例患者死亡,死亡率为1.9%,各亚型FBD死亡率差异存在显著性（P〈0.05）,功能性便秘死亡率最高;9例患者发生肠道器质性病变,3例（1.1%）为结肠癌,6例（2.3%）为结肠息肉,各亚型FBD患者肠癌发生率差异存在显著性（P〈0.01）,功能性便秘最高,各亚型FBD患者随访中结肠息肉发生率差异无显著性（P〉0.05）。结论 FBD总体不增加人群的死亡风险。但其中功能性便秘可能增加致死率。FBD患者中结肠癌发生率可能较普通人群增高,特别是功能性便秘患者结肠癌的发病率明显增高。【Objective】To analyze the mortality and the possible relationship with the incidence of intestinal organic disease of FBD, survival status and incidence of intestinal organic disease in patients with functional bowel disorders（FBD） followed-up.【Methods】Patients with bowel symptoms attended the Department of Gastroenterology at Nanjing Jiangbei People＇s Hospital between January 2005 and December 2006 were collected continuously.Patients more than 18 years of age, satisfied the Rome III criteria for FBD were included and followed up with telephone interview and/or out-patient review 5 years after their first attending. The survival status of the patients and incidence of intestinal organic disease were recorded. 【Results】263 cases of FBD patients were followed-up with dropout rate of 15.7%. 5 patients（1.9%） were died, the mortality of each FBD subtypes was different（P 0.05）,and the functional constipation with the highest mortality rate. 9 cases with intestinal organic disease, three cases（1.1%） for colonic cancer and 6 cases（2.3%） for colonic polyps. Significant difference of colonic cancer incidence in each FBD subtypes existed（P 0.01）, in which functional constipation with the highest incidence. The incidence of colonic polyps in various subtypes of FBD patients was similar（P 0.05）.【Conclusion】FBD does not increase the risk of death. However, the mortality of patients with functional constipation may increase. Incidence of colonic cancer in patients with FBD may be increased compared to that in the general population, especially increased in patients with functional constipation.

关 键 词：功能性肠病 随访 死亡率 结肠癌 结肠息肉 

分 类 号：R574.4[医药卫生—消化系统] R449[医药卫生—内科学]