不同放射剂量放疗对预防食道癌食道支架置入后再狭窄的临床研究  

The clinical study of different-dose radiotherapy for the prevention of restenosis after esophageal stent placement

作　　者：李兆滔[1] 吕志倩[2] 崔西玉[1] 张艳[1] 

机构地区：[1]广东省佛山市第一人民医院消化内科,广东佛山528000 [2]广东省佛山市第一人民医院放疗科,广东佛山528000

出　　处：《中国内镜杂志》2013年第12期1312-1314,共3页China Journal of Endoscopy

摘　　要：目的评价食管内支架置入联合不同放射剂量放疗对预防支架再狭窄的临床可行性和疗效。方法75例晚期食管癌行食道支架置入术患者,比较对照组、大剂量放疗组(60 Gy/6周)、小剂量放疗组(46 Gy/4.5周)患者的支架再狭窄率和生存率、并发症发生率。结果放疗组的支架再狭窄率低于对照组,但大剂量放疗组的出血并发症发生率高于小剂量放疗组(P<0.05)。3组患者的生存率差异无显著性。结论联合小剂量放射治疗能降低食管癌患者支架置入后再狭窄率,且能减少放疗并发症的发生率。【Objective】To evaluate clinical feasibility and efficacy of esophageal stent placement combined with different dose of radiotherapy for the prevention of stent restenosis. 【Methods】In 75 cases of advanced esophageal carcinoma of esophageal stenting, restenosis rate, survival rate and complication rate were compared among the control group, high-dose radiotherapy group（60 Gy/6 w） and low-dose radiotherapy group（46 Gy/4.5 w）.【Results】The stent restenosis rate of radiotherapy group was lower than in the control group, but the bleeding complication of high dose of radiotherapy group was higher than that in low dose radiation group（P 0.05）. Survival differences between three groups were of no significance. 【Conclusion】Combined with small doses of radiation therapy could reduce restenosis rate after the esophageal stent placement in patients with carcinoma, incidence rate and complications of radiotherapy.

关 键 词：放疗 食道癌 食道支架 狭窄 

分 类 号：R735.1[医药卫生—肿瘤]