两种剂量维甲酸治疗早幼粒白血病临床分析  

Treatment of Acute Promyelocytic Leukemia with two kinds of dose All-trans Retinoic Acid

作　　者：殷果[1] 刘传勇[1] 古茂群[1] 容中旺[1] 

机构地区：[1]广东省茂名市人民医院血液科,广东茂名525000

出　　处：《河北医学》2001年第1期20-21,共2页Hebei Medicine

摘　　要：目的 :观察两种不同剂量的全反式维甲酸 (ATRA)治疗急性早幼粒细胞白血病 (APL)的疗效及其副作用。方法 :采用小剂量全反式维甲酸 (ATRA)治疗急性早幼粒细胞白血病 (APL) 2 2例 ,与常规量历史组比较。结果 :1小剂量 ATRA同样有较高的 CR率 (90 .9% )。达 CR时间不延长。2小剂量 ATRA不降低高白细胞血症的发生率。3小剂量 ATRA治疗的副作用可减少、减轻 ,无 1例发生维甲酸综合征 (RAS)。结论 :两种剂量的 ATRA治疗 APL疗效相近 ,但小剂量 ATRA可降低Objective: [ST5BZ]To observe the curative effect and side effect with two different dosages ATRA are used in APL.[WT5HZ]Methods: We treated 22 Patients of acute Promyelocytic Leukemia(APL)with low dose all trans retinoic acid(ATRA).By means of comparing with routine dose group.[WT5HZ]Results: ①LD ATRA group also had high complete remission rdte(90.9%),the duration of CR was not Prolonged,The ②occured rate of Leukocytosis in LD group was not decreased.③The side effects in LD group were decreaed.No patient occured“Retinoic Acid Syndrome.”[WT5HZ]Conclusions: The curaive effects of two differen dosage are similar,but the small dosage could reduce the side effect. [WT5HZ]

关 键 词：全反式维甲酸 早幼粒细胞白血病 药物治疗 剂量 急性 

分 类 号：R733.7[医药卫生—肿瘤]