诱导多功能干细胞源性肝细胞治疗肝功能衰竭的研究进展  

Progress of treating hepatic failure with induced pluripotent stem cell-derived hepatocytes

作　　者：肖磊[1] 李军根[1] 刘运来[2] 

机构地区：[1]400038重庆,第三军医大学学员旅四营 [2]第三军医大学组胚教研室

出　　处：《国际生物医学工程杂志》2014年第1期49-52,共4页International Journal of Biomedical Engineering

基　　金：国家973项目（2010CB529400）

摘　　要：肝细胞移植治疗多种原因造成的肝功能衰竭,在临床上已取得较好的疗效.诱导多功能干细胞（iPS）及其定向分化技术的进步,为获得大量、安全及具有生物学功能活性的肝细胞移植所需的种子细胞提供了一种新的方法.对iPS定向分化成肝细胞并应用于肝细胞移植治疗肝功能衰竭的研究进展进行综述.Hepatocyte transplantation is effective in the treatment of liver failure caused by a variety of factors.In pace with the progress of the study of induced pluripotent stem cells and its differentiation technology,a new method has arisen to obtain a great number of safe hepatocytes with biological function,which are suitable for seed cells of hepatocyte transplantation.In this article,we review the latest research progress about induced pluripotent stem cell-derived hepatocytes being transplanted to treat liver failure.

关 键 词：诱导多功能干细胞 胚胎干细胞 肝功能衰竭 肝细胞移植 

分 类 号：R575.3[医药卫生—消化系统]