反流性食管炎的流行病学及临床研究  

Reflux esophagitis : epidemiology＆ clinical study

作　　者：王进海[1] 罗金燕[1] 龚均[1] 陶明[2] 

机构地区：[1]西安交通大学第二医院,710004 [2]西安交通大学医学院预防医学系

出　　处：《中华消化内镜杂志》2000年第6期345-348,共4页Chinese Journal of Digestive Endoscopy

摘　　要：目的了解西安地区成人反流性食管炎 (RE)流行病学情况 ,探讨 RE发生的危险因素。方法采用分层多级整群随机抽样问卷方法对西安市 18～ 70岁城乡常住人口共 2 532人进行了 RE相关症状的流行病学调查；根据 RE主要症状积分，随机抽取其中 140例和 54例有 RE相关症状的门诊患者接受了胃镜检查。结果西安地区成人 RE的发生率为 2.41％， RE主要症状的发生率为 16.98％； RE症状轻重与 RE发生率高低有关， P< 0.05～ 0.01，但 RE内镜下分级与症状严重程度无关 ,P >0.05；大量吸烟、大量饮酒、脑病、消化性溃疡、腹部手术是 RE主要症状发生的高危因素 (OR >2.6），肥胖是中危因素（ OR=1.7～ 2.5）；过饱食物、咖啡和甜食是低危因素（ OR=1.2～ 1.6）。结论西安地区成人中 RE常见 ,某些疾病、食物和生活习惯与 RE发生有关。Objective The prevalence of reflux esophagitis (RE) in adult population around Xi’ an area and its risk factors were explored. Methods An epidemiologic survey was carried out by means of a stratified random sample of 2 532 people aged 18～ 70 years living in Xi’ an district through standardized questionaire.Endoscopy was performed on 54 OPD patients with RE symptoms and 140 subjects under investigation who had complaints suggestive of RE. Results In this area the prevalence of RE and major symptoms of RE was 2.41 and 16.98 percent respectively. The incidence of RE in adults with symptoms being 27 percent.The severity of symptom had no influence on endoscopic grading (P >0.05), yet it correlated with RE incidence (P< 0.05～ 0.01 ),i.e.the severer the symptom, the higher the incidence of RE.The risk factors included heavy smoking, alcoholism, encephalopathy,peptic ulcer,abdominal surgery ( OR >2.6 ,high risk ),obesity( OR=1.7～ 2.5,moderate risk ),over ingestion and intake of coffee and sweets ( OR=1.2～ 1.6,low risk ). Conclusion RE is frequently seen in adult population around Xi’ an area with a variety of risk factors.

关 键 词：反流性食管炎 流行病学 危险因素 

分 类 号：R571[医药卫生—消化系统]