唇粘膜活检在脑淀粉样出血性血管病的临床应用研究  

Lip mucosa biopsy in clinical application of cerebral amyloid hemorrhagic cerebrovascular disease

作　　者：郑昆文[1] 张雯[2] 武绍远[1] 

机构地区：[1]云南省第一人民医院神经内科,云南昆明650032 [2]云南省第一人民医院基础研究所,云南昆明650032

出　　处：《世界最新医学信息文摘》2013年第23期26-27,共2页World Latest Medicine Information Electronic Version

基　　金：云南省卫生内设研究机构项目

摘　　要：自发性脑出血是一种急危重症,病死率和致残率高。而脑淀粉样血管病（cerebral amyloid angiopathy,caa）就能造成脑出血。由于受一些因素的限制，如脑组织取材难、诊断的阳性率低等，导致临床诊断几率低，有时只能检验尸体才能诊断出。因此，尽早、及时地预测脑淀粉样出血性血管病发生和发展的过程，从而对即将发生的脑淀粉样出血性血管病进行前瞻性、干预性治疗（针对不同病因），对减少脑淀粉样出血性血管病的发生、降低脑淀粉样出血性血管病后遗症及死亡率、提高人口素质有极其重要的意义。目前小样本预研究观察结果显示：唇粘膜活检行刚果红染色法与脑淀粉样出血性血管病有相关性。唇粘膜活检是一种简单、易行、创伤小的取材方法，其费用低，患者及正常人群易接受，可广泛应用于脑淀粉样血管病早期筛查，早期干预，早期治疗。但需进一步扩大样本量研究唇粘膜活检行刚果红染色法对脑淀粉样出血性血管病的灵敏性、特异性及吻合率，探索在脑淀粉样出血性血管病的临床诊断及应用价值。从而早期对其进行干预性治疗，最终减少发病率，降低高危人群的死亡率及致残率。spontaneous cerebral hemorrhage is a severe acute disease with high mortality and morbidity. cerebral amyloid angiopathy is one of the main causes of cerebral hemorrhage. Due to some limited factors, such as difficulty of drawing materials from brain tissue, low tissue specificity from pathological diagnosis, and low rate of positive diagnosis, it leads to low clinical diagnosis rate, thus could even rely on autopsy diagnosis. To predict the process of the occurrence and development of cerebral amyloid hemorrhagic angiopathy in time as early as possible, so as to proceed prospective, interventional therapy （according to different causes） towards impending cerebral amyloid hemorrhagic angiopathy, which has an important significance on decreasing the occurrence of cerebral amyloid hemorrhagic angiopathy, reducing sequelae and mortality of cerebral amyloid hemorrhagic angiopathy, and improving population quality. The small sample preliminary study results show that： the labial mucosa biopsy with congo red staining method has correlation with cerebral amyloid hemorrhagic angiopathy. labial mucosa biopsy is a simple, easy, small trauma based method, with a low cost, and is easily accepted by patients and normal people, which can be widely used in early screening, early intervention and early treatment of cerebral amyloid angiopathy. But there is great need in enlarging sample size to further study the sensitivity, specificity and match rate of lip mucosa biopsy with Congo red staining method on cerebral amyloid hemorrhagic angiopathy, and exploring the clinical diagnosis and application value in cerebral amyloid hemorrhagic angiopathy. So as to proceed early interventional treatment on it, and eventually reduce the incidence of the disease, as well as mortality and morbidity for high risky population.

关 键 词：唇粘膜活检 刚果红染色 脑淀粉样出血性血管病 

分 类 号：R743.3[医药卫生—神经病学与精神病学]