308nm准分子激光治疗对白癜风患者外周血Th1及Th2细胞因子的影响  

Effect of 308nm excimer laser therapy on Th1/Th2 cytokines in peripheral blood of patients with vitiligo

作　　者：李建英[1] 刘津民 曹海育[1] 张玉红[2] 刘英权[1] 

机构地区：[1]河北省石家庄市第一医院皮肤科,河北石家庄050011 [2]河北省石家庄市第一医院理疗科,河北石家庄050011

出　　处：《河北中医》2014年第3期479-480,共2页Hebei Journal of Traditional Chinese Medicine

基　　金：2012年河北省科学技术研究与发展计划项目(编号:12277724)

摘　　要：目的研究308 nm准分子激光对白癜风患者外周血Th1型细胞因子干扰素γ(IFN-γ)和Th2型细胞因子白细胞介素-4(IL-4)水平的影响,探讨其可能的作用机制。方法 50例白癜风患者均采用308 nm准分子激光治疗,每周2次共治疗24次。采用酶联免疫吸附法(ELISA法)检测50例白癜风患者治疗前、后及20例正常健康者外周血IFN-γ及IL-4的水平,并统计临床疗效。结果治疗组治疗前IFN-γ水平较正常对照组升高,比较差异有统计学意义(P<0.05);治疗后较治疗前明显降低(P<0.05),且与正常对照组比较差异无统计学意义(P>0.05)。治疗组治疗前IL-4水平与正常对照组及本组治疗后比较差异均无统计学意义(P>0.05)。结论白癜风患者体内Th1型细胞因子占优势,308 nm准分子激光可恢复白癜风患者Th1及Th2的平衡状态。Objective To study the level of Th1 cytokine（IFN-γ） and Th2 cytokine （IL-4） in peripher-al blood of patients with vitiligo , and to explore the possible immune mechanism of 308 nm excimer laser for vitiligo therapy.Methods 50 cases of vitiligo were treated by 308nm excimer laser therapy , twice a week for 24 times.The level of IFN-γand IL-4 in peripheral blood from 50 vitiligo patients before and after treatment and 20 healthy per-son in control group were measured by enzyme linked immunosorbent assay .Results There was no difference be-tween two groups on the level of IL -4 （P＆gt;0.05）.The level of IFN-γin vitiligo patients was higher than that in the control group （P＆lt;0.05）; After 308nm excimer laser therapy the level of IFN -γin vitiligo patients was dis-creased significanlty （P＆lt;0.05）.There was no significant difference between two groups after treatment （P＆gt;0.05）. Conclusion Th1 cytokine take advantage of vitiligo patients and involved in the pathogenesis of vitiligo .308nm ex-cimer laser therapy can restore the Th 1/Th2 balance .

关 键 词：白癜风 激光 准分子 干扰素Ⅱ型 白细胞介素4 INTERFERON-Γ INTERLEUKIN-4 

分 类 号：R758.410.5[医药卫生—皮肤病学与性病学] R454.21[医药卫生—临床医学]