体重指数和腰臀比预测非酒精性脂肪性肝病发病风险的比较  

Comparison of body mass index and waist-to-hip ratio for predicting of non-alcoholic fatty liver disease

作　　者：李爱玲[1] 谢云[1] 李瑾[1] 赵诗钰 

机构地区：[1]300070,天津医科大学代谢病医院神经内科

出　　处：《国际内分泌代谢杂志》2014年第2期135-137,共3页International Journal of Endocrinology and Metabolism

摘　　要：目的 分析非酒精性脂肪性肝病（NAFLD）的危险因素,探讨NAFLD与体重指数、腰臀比的关系.方法 选取天津医科大学代谢病医院住院患者及同期门诊患者共474例,依据2010年中国NAFLD诊疗指南,结合肝脏B超结果,将其分为NAFLD组（n=189）和非NAFLD组（n=285例）.回顾性分析两组患者腰臀比、体重指数、收缩压、舒张压、血脂谱等各项临床指标,采用多因素Logistic回归分析发生NAFLD的独立危险因素,并采用受试者工作特征曲线（ROC曲线）比较体重指数和腰臀比预测NAFLD的发病风险.结果 Logistic回归分析显示：腰臀比（P=0.000）、收缩压（P=0.029）、糖尿病病史（P =0.003）、总胆固醇（P =0.000）、甘油三酯（P=0.003）、高密度脂蛋白-胆固醇（P =0.015）为NAFLD的独立危险因素；ROC曲线结果显示,腰臀比的曲线下面积（AUC）、敏感性分别为0.825,0.799,体重指数的AUC、敏感性分别为0.755,0.593,P=0.000.结论 与体重指数升高相比,腰臀比升高的患者,发生NAFLD的风险更高,腰臀比较体重指数更能预测NAFLD的发生.Objective To investigate the risk factors of non-alcoholic fatty liver disease （NAFLD）,and the association of NAFLD with body mass index（BMI） and waist-to-hip ratio（WHR）.Methods 474 in-patients and out-patients from The Metabolic Disease Hospital of Tianjin Medical University were divided into NAFLD group （n =189） and non-NAFLD group （n =285） according to the guidelines of prevention and treatment of NAFLD among Chinese adults and the results of liver ultrasonic images.Clinical indicators were analyzed and compared between groups.The independent risk factors were analyzed by multiple regression,and Logistic regression.The association of NAFLD with BMI and WHR were analyzed by the receiver operating characteristic curve（ROC curve）.Results The independent risk factors for NAFLD were WHR（P =0.000）,systolic pressure（P =0.029）,history of diabetes mellitus （P =0.003）,total cholesterol （P =0.000）,triglyceride （P =0.003）,high density lipopmtein-cholesterol （P =0.015） in Logistic regression.The result of ROC curve showed that the AUC and sensitivity of WHR （0.825,0.799） were higher than those of BMI（0.755,0.593）,P =0.000 . Conclusion Compared with BMI,the risk of NAFLD increases more with the higher WHR and WHR is a better predictor of NAFLD than BMI.

关 键 词：非酒精性脂肪性肝病 体重指数 腰臀比 

分 类 号：R575.5[医药卫生—消化系统]