派特灵对宫颈高危型人乳头瘤病毒感染转归的影响  

Effect of paiteling on outcome of high-risk human papillomavirus infection of the cervix

作　　者：陶萍萍[1] 寿清和[2] 王运根[2] 郑伟平[2] 单江静[2] 陈君霞[2] 孙爱静[2] 孟晓华[2] 

机构地区：[1]上海市浦东新区人民医院妇产科,201200 [2]绍兴市人民医院妇科,312000

出　　处：《国际流行病学传染病学杂志》2014年第1期28-32,共5页International Journal of Epidemiology and Infectious Disease

基　　金：浙江省绍兴市社会发展重点科研项目（2011A23017）;上海市浦东新区卫生系统学科带头人培养计划（PWRd2013-09）

摘　　要：目的 研究派特灵宫颈上药对宫颈高危型HPV（HR-HPV）感染转归的影响.方法 以2011年1月至2013年6月在绍兴市人民医院确诊为HR-HPV亚临床感染者321例为研究对象,根据宫颈上皮内瘤样病变（CIN）的程度分为宫颈局部环形电切术（LEEP）组（手术组）和非手术组.两组在诊断后根据随机数字表法,分别再细分为上药组和对照组.手术组共82例,其中上药组42例,对照组40例；非手术组共239例,其中上药组109例,对照组130例.上药组用中药制剂派特灵宫颈局部上药,对照组随访观察.每3月复查HR-HPV及共一年.分析比较不同时期HPV转阴率及病灶消退情况.结果 非手术组随访6、9和12个月时,上药组HPV转阴率分别为83.9％、89.5％和95.2％,均高于对照组,差异有统计学意义（x2=66.996、60.270、19.834,P均＜0.01）；上药组病灶消退率分别为84.8％、85.7％和91.3％,均高于对照组,差异有统计学意义（x2=66.799、35.783、32.778,P均＜0.01）.手术组术后,上药组HPV转阴率分别为83.3％ 、90.0％和95.0％,均高于对照组,差异有统计学意义（x2=4.431、4.101、4.851,P均＜0.05）,但两组的病灶消退率差异无统计学意义（x2=2.736、0.330、0.034,P均＞0.05）.结论 派特灵宫颈上药可以加快HPV病毒的清除,缩短HPV感染持续时间,促进宫颈病灶消退,加快LEEP术后残留病毒的清除.Objective To evaluate the effect of paiteling on outcome of high-risk human papillomavirus （HR-HPV） infection of the cervix.Methods Three hundred and twenty-one patients diagnosed as HR-HPV subclinical infection in Shaoxing People＇s Hospital from January 2011 to June 2013 were selected in the study.The patients were divided into loop electrosurgical excision procedure group （LEEP group,n=82） and non-LEEP group （n=239） in light of the cervical intraepithelial neoplasia classification.The two groups were subgrouped to paiteling group and control group by using random number table.In LEEP group,42 patients in paiteling and 40 in control subgroups; and in non-LEEP group,109 in paiteling and 130 in control subgroups.Paiteling was used in the cervix according to the instructions.The control subgroup had follow-up observation.All patients underwent TCT and HR-HPV test every 3 months for 1 year.The seroconversion rate of HR-HPV and the regression of cervical lesions were compared between the two subgroups.Results In non-LEEP group,the negative conversion rate of HR-HPV in paiteling subgroup at 6-,9-,and 12-months were 83.9%,89.5%,and 95.2%,respectively,which were higher than those in control subgroups with significant differences （x2=66.996,60.270,19.834,P all 〈 0.01）; the regression rate of cervical lesions in paiteling subgroup at 6-,9-,and 12-months were 84.8%,85.7%,and 91.3%,respectively,which were significantly higher than those in control subgroups （x2=66.799,35.783,32.778,P all 〈0.01）.After LEEP therapy,the seroconversion rate of paiteling subgroup at 6-,9-,and 12-months were 83.3%,90.0% and 95.0%,respectively,higher than those in control subgroups with significant differences （x2=66.996,60.270,19.834,P all 〈0.01）,but the regression rate of lesions did not differ between the two subgroups （x2=2.736,0.330,0.034,P all 〉0.05）.Conclusions Using paiteling in the cervix can speed up the clearance of HPV infection,shorten the persistence of HPV infection,and accelerate the regression

关 键 词：乳头状瘤病毒感染 基因型 派特灵 转归 清除率 

分 类 号：R737.33[医药卫生—肿瘤]