赭曲霉毒素A的肠毒性及其营养干预  

Intestinal Toxicity of Ochratoxin A and Its Nutritional Intervention

作　　者：范斌[1,2] 余冰[1,2] 王乐成[1,2] 田刚[1,2] 

机构地区：[1]四川农业大学动物营养研究所,成都611130 [2]动物抗病营养教育部重点实验室,成都611130

出　　处：《动物营养学报》2014年第2期334-341,共8页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：科技部科技成果转化项目"饲料霉菌毒素体内解毒技术的开发与应用(2012GB2F000399)";四川农业大学"双支计划"项目

摘　　要：赭曲霉毒素A(ochratoxin A,OTA)是一类主要由曲霉属和青霉属等产毒真菌产生的真菌毒素,广泛存在于各种粮食作物及其副产品中,是食品和饲料原料的重要污染物,其广泛的毒理病理学效应对动物生产和人类健康构成了极大的潜在危害,已引起了人们的高度关注。肠道既是OTA等外源有毒有害物质的主要吸收部位,又是阻挡其进入体循环的第1道物理屏障,同时还可能是其发挥毒性效应的靶器官。因此,本文就OTA的肠毒性及其作用机制、营养对OTA肠毒性的缓解效应做简要综述,以期为缓解OTA的肠毒性提供理论基础和实践依据。Ochratoxin A （ OTA） is a mycotoxins produced by toxigenic fungi, especially some species of As-pergillus and Penicillium.OTA widely exists in food crops and their by-products, which is known as an impor-tant contaminant of food and feed materials.Toxicological pathology studies showed that OTA had a great po-tential threat to animal reproduction and human health, which had resulted in the public attention highly.The intestine not only is the main absorption site of the toxic exogenous, such as OTA, but also is an organ where the exogenous toxins are blocked into the systemic circulation as the first physical barrier, meanwhile, the in-testine may be the target organ suffered from the toxicity hazard.This article focused on the intestinal toxicity of OTA and its mechanisms, as well as its nutritional intervention, in order to provide theoretical foundation and practice basis for relieving intestinal toxicity of OTA.

关 键 词：赭曲霉毒素A 肠毒性 作用机制 营养干预 

分 类 号：Q936[生物学—微生物学]