Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides  

作　　者：Jing XU Cheng-shi JIANG Zai-long ZHANG Wen-quan MA Yue-wei GUO 

机构地区：[1]College of Science, China University of Petroleum, Qingdao 266580, China [2]State Key Laboratory of Drug Research, Shanghai Insti-tute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China [3]Weifang Biomedical Innovation and Entrepreneur-ship Service Center, Weifang 261205, China

出　　处：《Acta Pharmacologica Sinica》2014年第3期316-330,共15页中国药理学报（英文版）

摘　　要：Macrolides, which comprise a family of lactones with different ring sizes, belong to the polyketide class of natural products. Resorcinolic macrolides, an important subgroup, possess interesting structures and exhibit a wide variety of bioactivities, such as anti- tumor, anti-bacteria, and anti-malaria activities, etc. This review summarizes progress in isolation, bioactivity studies, biosynthesis, and representative chemical syntheses of this group of macrolides in recent decades, encompassing 63 naturally occurring macrolides published in 120 articles.Macrolides, which comprise a family of lactones with different ring sizes, belong to the polyketide class of natural products. Resorcinolic macrolides, an important subgroup, possess interesting structures and exhibit a wide variety of bioactivities, such as anti- tumor, anti-bacteria, and anti-malaria activities, etc. This review summarizes progress in isolation, bioactivity studies, biosynthesis, and representative chemical syntheses of this group of macrolides in recent decades, encompassing 63 naturally occurring macrolides published in 120 articles.

关 键 词：natural product resorcinolic macrolide fungal metabolite bioactivity ANTI-TUMOR ANTI-BACTERIA anti-malaria BIOSYNTHESIS 

分 类 号：S859.796[农业科学—临床兽医学] S482.39[农业科学—兽医学]