Correlation between serum CEA levels and EGFR mutations in Chinese nonsmokers with lung adenocarcinoma  

作　　者：Bo JIN Yu DONG Hui-min WANG Jin-su HUANG Bao-hui HAN 

机构地区：[1]Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China

出　　处：《Acta Pharmacologica Sinica》2014年第3期373-380,共8页中国药理学报（英文版）

摘　　要：Aim： To evaluate the relationship between epidermal growth factor receptor （EGFR） mutations and serum carcinoembryonic antigen （CEA） levels in Chinese nonsmokers with pulmonary adenocarcinoma. Methods： We sequenced exons 18-21 of the EGFR gene in 98 cases. The patients were divided into two groups based on their pre- treatment serum CEA levels （below or above 5 n~/mL） for analyzing the correlations with EGFR mutations. Results： Sixty-seven cases harbored EGFR mutations. The rates of EGFR mutations and exon 19 mutations in the high-CEA group （78.2% and 49.1%, respectively） were significantly higher than those in the Iow-CEA group （55.8% and 20.9%, respectively）. Serum CEA levels were found to be the only independent predictor of EGFR mutation （OR 2.837; 95% CI： 1.178-6.829） and exon 19 mutation （OR 3.618; 95% CI： 1.319-9.918）. Furthermore, a higher serum CEA level was associated with a higher EGFR mutation rate and a higher exon 19 mutation rate： patients with serum CEA levels 〈5 ng/mL, 〉5 and 〈20 ng/mL, 〉20 ng/mL showed the EGFR mutation rate of 55.8%, 74.1%, 82.1%, respectively, and the exon ：19 mutation rate of 20.9%, 40.7%, 57.1%, respectively. Patients with EGFR mutations displayed a significantly higher incidence of abnormal serum CEA levels （〉5 ng/mL） than patients without EGFR mutations （64.2% vs 38.7%）. Conclusion： Elevated serum CEA levels predict the presence of EGFR gene mutations in Chinese nonsmokers with pulmonary adenocarcinoma.Aim： To evaluate the relationship between epidermal growth factor receptor （EGFR） mutations and serum carcinoembryonic antigen （CEA） levels in Chinese nonsmokers with pulmonary adenocarcinoma. Methods： We sequenced exons 18-21 of the EGFR gene in 98 cases. The patients were divided into two groups based on their pre- treatment serum CEA levels （below or above 5 n~/mL） for analyzing the correlations with EGFR mutations. Results： Sixty-seven cases harbored EGFR mutations. The rates of EGFR mutations and exon 19 mutations in the high-CEA group （78.2% and 49.1%, respectively） were significantly higher than those in the Iow-CEA group （55.8% and 20.9%, respectively）. Serum CEA levels were found to be the only independent predictor of EGFR mutation （OR 2.837; 95% CI： 1.178-6.829） and exon 19 mutation （OR 3.618; 95% CI： 1.319-9.918）. Furthermore, a higher serum CEA level was associated with a higher EGFR mutation rate and a higher exon 19 mutation rate： patients with serum CEA levels 〈5 ng/mL, 〉5 and 〈20 ng/mL, 〉20 ng/mL showed the EGFR mutation rate of 55.8%, 74.1%, 82.1%, respectively, and the exon ：19 mutation rate of 20.9%, 40.7%, 57.1%, respectively. Patients with EGFR mutations displayed a significantly higher incidence of abnormal serum CEA levels （〉5 ng/mL） than patients without EGFR mutations （64.2% vs 38.7%）. Conclusion： Elevated serum CEA levels predict the presence of EGFR gene mutations in Chinese nonsmokers with pulmonary adenocarcinoma.

关 键 词：lung cancer ADENOCARCINOMA BIOMARKER carcinoembryonic antigen EGFR mutation exon 19 deletion nonsmoker 

分 类 号：Q754[生物学—分子生物学] S828.1[农业科学—畜牧学]