高危型人乳头瘤病毒在宫颈病变筛查中的临床价值  

The Clinical Value of High-risk Human Papilloma Virus in the Screening Patients with Cervical Lesions

作　　者：韩全贵[1] 白宝琴[1] 马婷婷[1] 李自润 

机构地区：[1]大同市第三人民医院病理科,山西大同037008 [2]山西大同大学医学院,山西大同037009

出　　处：《山西大同大学学报（自然科学版）》2014年第1期59-60,88,共3页Journal of Shanxi Datong University(Natural Science Edition)

摘　　要：目的探讨高危型人乳头瘤病毒(HPV)在宫颈病变筛查中的临床价值。方法利用宫颈液基细胞学(TCT)检测4类宫颈病变病人,包括ASC-US,LSIL,ASC-H和HSIL,运用DNA基因捕获技术(HC2)检测上述4类病人的HPV值,并分析HPV值与各类宫颈病变病人的关系。结果 4类宫颈病变病人中,HPV阳性检出率平均为38%,其中HSIL病人中,HPV阳性检出率最高,同时HPV阳性值最高。结论宫颈液基细胞学联合HPV-DNA检测在宫颈癌癌前病变筛查中具有重要的临床应用价值。Objective To investigate the clinical value of high-risk human papilloma virus （HPV） in the screening patients with cervical lesion. Methods Four kinds of cervical lesion patients including the ASC-US, LSIL, ASC-H, HSIL were detected using liquid based cytology. Using DNA gene capture technology we detected HPV value of the above four kinds of patients, and analyzed the rela- tionships of HPV value and all kinds of cervical lesions patients. Results In the four kinds of patients with cervical pathological chang- es, an average of the HPV positive detection rates was 38%. With HSIL patients, the HPV positive detection rates was the highest, while HPV positive values was the highest. Conclusion Cervical liquid based cytology combined with HPV - DNA testing in the screen- ing patients with cervical precancerous lesions had an important clinical value.

关 键 词：宫颈病变 HPV TCT 杂交捕获技术 

分 类 号：R361.2[医药卫生—病理学] R737.33[医药卫生—基础医学]