Advances in research on Shadoo, shadow of prion protein  

作　　者：Siqi Wang Hui Zhao Yaping Zhang 

机构地区：[1]Laboratory for Conservation and Utilization of Bio-resource,Yunnan University [2]State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology, Chinese Academy of Sciences

出　　处：《Chinese Science Bulletin》2014年第9期821-827,共7页

基　　金：supported by the National Natural Science Foundation of China(31060302,31260032);the Natural Science Foundation of Yunnan Province(2010CD010)

摘　　要：Prion plays a central role in the pathogenesis of transmissible spongiform encephalopathies,also known as prion diseases.However,the biology of the protein and the pathophysiology of these diseases remain largely unknown.It has been speculated that additional factor or factors may be involved in the pathogenesis of prion diseases.Recently,a PrP-like protein,recognized as shadow of prion protein(Shadoo,Sho),is thought to be an interesting candidate factor because both the prion protein and Sho have been shown to have overlapping expression patterns and shared functions.Therefore,extensive study of Sho may advance our understanding of the enigmatical biology of prion and prion diseases.In this review,recent studies on Sho associated with prion diseases and functions are summarized.These studies have demonstrated the functional importance of Sho,and they further need to investigate its biological roles in prion diseases.Prion plays a central role in the pathogenesis of transmissible spongiform encephalopathies, also known as prion diseases. However, the biology of the protein and the pathophysiology of these diseases remain largely unknown. It has been speculated that additional factor or factors may be involved in the pathogenesis of prion diseases. Recently, a PrP-like protein, recognized as shadow of prion protein （Shadoo, Sho）, is thought to be an interesting candidate factor because both the prion protein and Sho have been shown to have overlapping expression patterns and shared functions. Therefore, extensive study of Sho may advance our understanding of the enigmatical biology of prion and prion diseases. In this review, recent studies on Sho asso- ciated with prion diseases and functions are summarized. These studies have demonstrated the functional importance of Sho, and they further need to investigate its biological roles in prion diseases.

关 键 词：阴影 朊蛋白 传染性海绵状脑病 生物学作用 朊病毒病 朊病毒蛋白 朊病毒疾病 发病机制 

分 类 号：R373[医药卫生—病原生物学]