噻吗洛尔滴眼液对高度近视LASIK术后角膜后表面影响  

Timolol eye drops＇s influence on posterior corneal surface height of high myopia after LASIK

作　　者：刘育霞[1] 王平[1] 

机构地区：[1]潍坊医学院附属医院眼科,山东261031

出　　处：《中国实用眼科杂志》2014年第3期338-340,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的应用降眼压药物噻吗洛尔滴眼，观察降低眼压对高度近视LASIK术后角膜后表面高度的影响，推断LASIK术后角膜前凸的影响因素。方法对2011年7～12月在潍坊医学院附属医院眼科符合LASIK手术适应证的高度近视患者30例（60只眼）行标准LASIK术，术后第1天开始滴用0．5％马来酸噻吗洛尔眼液2次／d，共1个月，观察术前及术后1d、1周、2周、1个月时眼压及角膜后表面高度的变化。结果高度近视患者LASIK术后第1天角膜已前凸，角膜后表面高度值较术前增大，差异有统计学意义（P〈0．05）。应用噻吗洛尔降眼压后1周、2周、1个月角膜后表面高度值仍持续增大，与术前及术后1d相比，差异均有统计学意义（P〈0．05）。结论噻吗洛尔滴眼液能够降低高度近视LASIK术后眼压值，但降低眼压不能阻止角膜后表面高度值的增大，角膜仍持续前凸，因此推断眼压不是影响高度近视LASIK术后角膜后表面高度的因素，至少不是主要因素。Objective To infer influencing factors of cornea lordosis through observing timolol eye drop influence on posterior comeal surface height of high myopia after LASIK. Methods Thir- ty high myopia （60 eyes） in line with LASIK indications were received standard LASIK, 0.5% timo- 1ol maleate eye drops （2 times per day） started to use from the first day after operation, the Chang- es of intraocular pressure and posterior corneal surface height on pre-operation, and post-operation 1 day, 1 week, 2 weeks, and 1 month were observed. Results The comea of high myopia after LASIK had lordosised on the first day after operation, and the data of posterior comeal surface height increased comparing with pre-operation, the difference was statistically significant. The data of posterior corneal surface height after using timolol eye drops 1 week, 2 weeks, 1 month continuous- ly increased comparing with pre-operation and 1 day after operation, the differences were all statisti- cally significant. Conclusions Timolol eye drops can reduce intraocular pressure of high myopia af- ter LASIK, but it can＇t prevent the data of posterior corneal surface height from increasing, cornea still continue lordosising. Therefore, intraocular pressure isn＇t the influencing factor of posterior cor- neal surface height of high myopia after LASIK, at least not the main factor.

关 键 词：噻吗洛尔 高度近视 LASIK 角膜后表面 

分 类 号：R779.6[医药卫生—眼科]