β射线放射治疗角膜新生血管观察  

Clinical observation of β-radiotherapy for corneal neovascularization

作　　者：董贺[1] 徐少凯[1] 林松[1] 张繁友[1] 

机构地区：[1]大连医科大学附属大连市第三人民医院眼科,116031

出　　处：《中国实用眼科杂志》2014年第3期348-352,共5页Chinese Journal of Practical Ophthalmology

摘　　要：目的评价B射线放射治疗患者角膜新生血管（CNV）的临床效果。方法对2008年8月至2011年7月在大连市第三人民医院眼科应用^90Sr-^90Y眼科敷贴器对8例（8只眼）角膜新生血管患者行B射线放射治疗。治疗期间每日检查视力、眼压，1周、2周、1个月及2个月随诊行裂隙灯显微镜观察并照像，应用角膜新生血管面积计算公式，面积A（mm^2）=CH／12×3．14[r^2-（r-VL）^2]来评价疗效。结果6只眼经8射线放射治疗后角膜新生血管明显消退。8只眼CNV充血程度均明显减轻。视力有不同程度提高或无变化，但无下降趋势。放射剂量控制在16Gy以下，对比治疗前后，角膜可出现轻度水肿，但均自行消退。未发现明显的角膜损伤、前房炎症反应、晶状体损伤及眼底变化，未出现局部和全身副反应。结论β射线放射治疗患者角膜新生血管安全有效，对于粗大血管可以进一步探索安全的照射剂量。Objective To assess the clinical effect of 13 irradiation treatment on patients with corneal neovascularization （CNV）. Methods The clinical effect of 13 irradiation treatment on 8 patients （8 eyes） of corneal neovascularization by ^90Sr-^90Y ophthalmic applicator was observed. Visual acu- ities and intraocular pressure were recorded daily during the treatment. Follow-up time was 1 week, 2 weeks, 1 month and 2 months. Observe with the slit lamp and took pictures, the clinical effect with corneal neovascularization area computation formula A（mm2）=CH/12×3.14[r^2-（r-VL）^2] were as- sessed. Results CNV of 6/8 eye was obviously resolved after the 13 irradiation treatment. Hyperae- mia was significantly regressed. Vision was improved or no changed, but no reduced. The radiation dose was controlled in the 16 gy. Contrast pre- and post- treatment appeared recuperative corneal em- eda. Significant injury of cornea, anterior chamber inflammation, lens injury, fundus change, local and systemic side effects were not found. Conclusions 13 irradiation treatment of CNV is safe and effective. May explores the safe dose for bulky blood vessels in further.

关 键 词：Β射线 放射疗法 角膜新生血管 临床观察 ^90Sr-^90Y眼科敷贴器 

分 类 号：R772.2[医药卫生—眼科]