淋巴结内栅栏状肌纤维母细胞瘤临床病理观察  

Clinicopathologic features of intranodal palisaded myofiborblastoma

作　　者：王建容[1] 张醇[1] 陈春燕[1] 阎晓初[2] 

机构地区：[1]武警重庆市总队医院病理科,重庆400061 [2]第三军医大学西南医院病理研究所,重庆400038

出　　处：《诊断病理学杂志》2014年第3期149-152,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨淋巴结内栅栏状肌纤维母细胞瘤的临床病理特点。方法观察1例腹股沟淋巴结内栅栏状肌纤维母细胞瘤的组织学及免疫表型,并复习相关文献。结果患者女性,51岁。左侧腹股沟无痛性包块4个月。镜下肿瘤由分化成熟的梭形瘤细胞呈栅栏状排列,伴石棉样纤维及肿瘤实质出血、裂隙状血管腔形成。免疫组化:瘤细胞vimentin、SMA、actin和cyclin D1(+),desmin、S-100、Syn、CD117、CD99、HMB45、melan-A、bcl-2、Factor-Ⅷ、CD34、EMA和AE1/AE3(-),Ki-67增殖指数2%。结论淋巴结内栅栏状肌纤维母细胞瘤是原发于淋巴结内罕见的良性间叶性肿瘤,结合影像学、病理学特征及免疫组化可确诊,预后良好。Objective To explore the elinicopathologic features of intranodal palisaded myofiborblastoma （IPM）. Methods The histological and immuaological phenotype in a case of IPM was studied and the related literatures were reviewed. Results A 51 -year-old woman presented with 4 months history of a painless nodule in the left inguinal region. Microscopically, the lesion was composed of bland looking spindle cells with area of nuclear palisading, amianthoid fibres and areas of fresh as we｜l as old hemorrhages. The spindle cells showed positive staining of vimentin, SMA and actin, cyclin D1, but negative for desmin, S-100, Syn, CDl17, CD99, HMB45, melan-A, bcl-2, factor-VIII, CD34, EMA and AE1/AE3, and low expression of Ki-67 was noted. Conclusion IPM, which possesses a good prognosis, is a rare benign mesenchymal tumor in lymph nodes. It can be diagnosed through imaging, elinicopathologic features and immunological phenotype.

关 键 词：淋巴结内栅栏状肌纤维母细胞瘤 腹股沟 石棉样纤维 

分 类 号：R730.26[医药卫生—肿瘤]