食物对细胞色素P450药物代谢酶的影响  

Effects of food on Cytochrome P450 drug metabolic enzymes

作　　者：章冉冉[1,2] 阳国平[2] 荆宁宁[1,2] 黄洁[1,2] 黄路[1,2] 王艳[1,2] 

机构地区：[1]中南大学药学院 [2]中南大学湘雅三医院

出　　处：《中国临床药理学与治疗学》2014年第2期200-206,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：重大疾病新药临床评价研究综合技术平台建设(2012ZX09303014-001);国家"重大新药创制"科技重大专项;湖南省自然基金重点项目(11JJ2054)

摘　　要：细胞色素P450酶系在大多数内源性和外源性分子的生物氧化过程中发挥重要的作用,尤其在药物代谢方面。CYP450酶个体差异大,除了遗传因素的影响外,食物等外界因素也可能影响其活性或表达,从而影响经酶代谢药物的疗效和不良反应。故本文就食物因素对细胞色素P450酶影响的相关研究进行综述。Cytochrome P450 （CYP450） en zymes play important roles in the biological oxi dation process of many endogenous and exoge nous moleculars, especially in drug metabolism. The great individual variations of the CYP450 enzymes among human subjects have been showed. In addition to the genetic factors, food and other environmental factors may also affect the activity and expression of CYP450 enzymes,which ultimately lead to the increased possibility of adverse reactions or toxicity. This review ar ticle summarizes the recent literatures with in terests in the effects of food on cytochrome P450.

关 键 词：食物 细胞色素P450酶 抑制 诱导 

分 类 号：R968[医药卫生—药理学]