白色念珠菌生物学特性研究进展  

Research progress in biological characteristics of Candida albicans

作　　者：江文俊[1] 姜福全[2] 崔彦[2] 

机构地区：[1]安徽医科大学解放军第306临床学院普通外科,北京100101 [2]解放军第306医院普通外科,北京100101

出　　处：《基础医学与临床》2014年第4期550-554,共5页Basic and Clinical Medicine

基　　金：全军医学科研"十二五"重点项目(BWS11J051)

摘　　要：白色念珠菌的毒力因素主要表现为对宿主细胞及组织的黏附性、菌丝的形成及分泌水解酶等三个方面。白色念珠菌的耐药机制和对周围环境的应激适应受多因素和多水平的调控,对白色念珠菌感染、耐药及应激过程中的机制尚需进一步探讨。With the increased application of broad-spectrum antibiotics, immunosuppression, and cytotoxic thera- pies, Candida albicans, as a conditioned pathogen, has become one of the common nosocomial infection pathogen. Recent studies showed that the pathogenicity of Candida albicans depends upon hypothetical virulence factors inclu- ding the adhesion to host cells, transition from yeast to mycelium, and production of secreted hydrolytic enzymes. The impacts on the evolution of drug resistance and adaptation to environmental stress rely on multiple machanisms and remain largely unexplored. Therefore, to understand the basic structure, genotype, pathogenesis, drug resist- ance of Candida albicans and the influence of environmental stress on Canclida albicans has great clinical signifi- cance for disease diagnosis, treatment and prevention.

关 键 词：白色念珠菌 基本结构 基因分型 致病 耐药 应激 

分 类 号：R379.4[医药卫生—病原生物学]