不同性别患者脑静脉窦血栓形成的临床特点  

The Clinical Features of Cerebral Vein and Sinus Thrombosis in Different Gendered Patients

作　　者：丁宏岩[1] 董强[1] 

机构地区：[1]复旦大学附属华山医院神经内科,200040

出　　处：《中国临床神经科学》2014年第1期88-93,共6页Chinese Journal of Clinical Neurosciences

摘　　要：目的分析不同性别患者脑静脉窦血栓形成(CVST)的临床特点。方法回顾性分析82例CVST患者的临床资料。结果 82例CVST患者中,男性52例、女性30例。病因不明:男性为42.3%,女性为20.0%(P<0.05);有5例女性(16.7%)患者与产褥期或服用避孕药相关。性发作:男性为40.4%,女性为13.3%(P<0.05)。不论性别,有实质病灶的患者中死亡或遗留神经功能缺损的比例为31.0%,无实质病灶的患者预后不良的比例为10.0%(P<0.05)。结论与女性相比,CVST男性患者病因不明的比例较高,性发作的风险高;有脑实质病变的患者预后较差。Aim To analyze the clinical features of cerebral vein and sinus thrombosis （CVST） in different gendered patients.Methods All the medical records,including sex,age,clinical manifestations,imaging,treatment and prognosis of 82 CVST patients in the past nine years in Huashan hospital were analyzed retrospectively.Results Of the 82 patients,52 men and 30 women,male patients aged from 15 to 73 （mean 37.4 ± 15.3） years old,female patients aged from 8 to 69 （mean 34.3 ± 14.7） years old,P=0.35.Male patients with indefinite causes accounted for 42.3%,20% for female patients （P〈0.05）.5 female patients （16.7%） were onset due to gender-specific risk factors （oral contraceptives,pregnancy,puerperium）,compared with the men,P=0.005.There was no difference between the men and women in other causes such as infection,blood diseases,autoimmune diseases,and tumor.Headache was the first symptom in most patients regardless of gender,40.4% men have seizures,13.3% in women （P〈0.05）.42 patients had parenchymal lesion,in which 13 patients （31%） died or remained neurological function deficits,in contrast to 4 patients （10%） had the similar prognosis in 40 patients who had no parenchymal damages （P〈0.05）.Conclusion Compared to the women,the male patients with CVST were more difficult to be confirmed causes and had a higher proportion of seizures.Female patients had a gender related risk factor.Patients with brain parenchymal lesions had worse prognosis.

关 键 词：脑静脉窦 血栓形成 性别 临床特点 

分 类 号：R743.32[医药卫生—神经病学与精神病学]