P63蛋白在宣威与非宣威地区非小细胞肺癌中表达的对比研究  

Comparison of P63 Protein Expression in Non-small Cell Lung Cancer between Xuanwei and Other Regions

作　　者：刘君[1,2] 李高峰[3,4] 陈楠[3,4] 彭俊[1,2] 陈新隆[1,2] 王平[1,2] 毛新[1,2] 宁显谷[1,2] 

机构地区：[1]云南省第一人民医院 [2]昆明理工大学附属昆华医院胸心血管外科,云南昆明650032 [3]昆明医科大学第三附属医院 [4]云南省肿瘤医院胸外科,云南昆明650118

出　　处：《昆明医科大学学报》2014年第1期37-41,共5页Journal of Kunming Medical University

摘　　要：目的研究宣威与非宣威地区非小细胞肺癌P63蛋白的表达,探讨其与生物学行为的关系.方法免疫组织化学法.结果 P63在肺鳞癌组织中高表达;非小细胞肺癌中,P63的表达与患者的TNM分期、组织分化程度及淋巴结转移情况有关,与患者性别无关;P63在非小细胞肺癌中在相同病理类型、分期、组织分化、淋巴结转移情况及相同性别的阳性表达率,宣威组与非宣威组比较,差异无统计学意义(P>0.05).结论 P63的表达在宣威并无地区特异性,并不是宣威肺癌高发的原因.Objective The purpose of the study was to compare the P63 expression in non-small cell lung cancer （NSCLC） between Xuanwei and other regions, and to investigate the relationship of P63 expression and biological behavior. Methods Immunohistochemical method was used. Results The results indicated that the expression of P63 in lung squamous cell carcinoma was extraordinarily high. P63 was related to the TNM staging system,tissue differentiation degree and lymph node metastasis,but not related to gender. In NSCLC,there was no significant difference of the P63 positive expression rate in the same pathological types, staging, tissue differentiation degree, lymph node metastasis and gender between Xuanwei and other regions. It indicated that the expression of P63 was not the reason why it was high incidence of lung cancer in Xuanwei region.

关 键 词：非小细胞肺癌 P63蛋白 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]