艾易舒对食管癌患者化疗后血浆D-二聚体水平的影响  

Effects of Sodium Cantharidinate and Vitamin B6 Injection on Plasma D-dimer Level in Patients of Advanced Esophageal Cancer after Chemotherapy

作　　者：朱辉[1] 张海燕[1] 何明[1] 陈新[1] 

机构地区：[1]河北医科大学第四医院胸外科,050011

出　　处：《天津医药》2014年第3期254-256,共3页Tianjin Medical Journal

基　　金：河北省卫生厅医学科学研究重点课题计划(项目编号:20090536)

摘　　要：目的研究艾易舒对食管癌化疗后患者血浆D-二聚体水平的影响及D-二聚体水平与临床病理特征之间的关系。方法经临床病理证实,不可手术的食管癌患者58例,分别于初次和第3次化疗(PF方案)前1 d行D-二聚体水平测定。20例同期健康查体志愿者作为健康对照。食管癌患者随机分为试验组与对照组,试验组自化疗第1天起给予艾易舒注射液,每日0.5 mg,持续化疗全程,对照组则给予等量生理盐水。结果化疗前食管癌患者血浆D-二聚体水平较健康对照组明显升高(P<0.05),不同性别、年龄、临床分期及病理类型食管癌患者间D-二聚体水平差异无统计学意义。化疗后食管癌患者D-二聚体水平较化疗前明显降低,试验组D-二聚体水平低于对照组(均P<0.05);试验组消化道不良反应及骨髓抑制发生比例均较对照组降低。结论食管癌患者血浆D-二聚体升高,化疗后明显下降;艾易舒联合化疗可进一步降低D-二聚体水平,减轻化疗不良反应。Objective To explore the effect of sodium cantharidinate and vitamin B6 injection on plasma D-dimer level in patients of advanced esophageal cancer after chemotherapy and the relationship between plasma D-dimer level and clinical pathological parameters thereof. Methods Fifty-eight patients with advanced esophageal cancer confirmed by path-ological examination were randomly divided into two groups. Twenty-nine patients （experimental group） received chemother-apy （PF chemotherapy） combined with sodium cantharidinate and vitamin B6 （0.5 mg once daily）. Twenty-nine patients （con-trol group） received same volume of saline. And there were 20 healthy volunteers as the normal control. The plasma D-dimer level was determined one day before the first cycle of chemotherapy and the third cycle of treatment. Results The plasma D-dimer level was significantly higher before chemotherapy in patients with advanced esophageal cancer than that in normal control group （P＆lt;0.05）. There were no significant differences in plasma D-dimer level between patient gender, age, clinical stage and pathological levels. The D-dimer level was significantly down-regulated after chemotherapy. The D-dimer level was significantly lower in experimental group than that in control group （P＆lt;0.05）. The incidences of digestive and hemato-logical adverse reactions were much lower in experimental group than those in control group. Conclusion The elevated plasma D-dimer level was found in patients with advanced esophageal cancer, and which was down-regulated by chemother-apy. The chemotherapy of sodium cantharidinate and vitamin B6 can further reduce the D-dimer level, and relieve the ad-verse reactions of chemotherapy.

关 键 词：食管肿瘤 癌 抗肿瘤联合化疗方案 D-二聚体 斑蝥酸钠 

分 类 号：R735.2[医药卫生—肿瘤]