眼缺血综合征实验动物模型的制备  

Establish of animal model of ocular ischemic syndrome

作　　者：安鑫(综述)[1] 谢国丽(审校)[1] 王艳玲(审校)[1] 

机构地区：[1]首都医科大学附属北京友谊医院眼科,100050

出　　处：《中华实验眼科杂志》2014年第3期285-288,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：北京市自然科学基金面上项目（7122046）

摘　　要：眼缺血综合征（OIS）是颈动脉阻塞或狭窄所致的脑和眼供血不足而产生的一系列脑和眼部症状,是一类涵盖眼科、神经内科等多学科的疾病.OIS发病机制尚不明确,起病隐匿,缺血严重程度不一,眼部及全身临床表现复杂多样,早期诊断困难,治疗效果及预后不佳.近年来关于OIS的实验研究成为探讨该病诊断和治疗的热点与焦点,建立较为理想的实验动物模型显得至关重要.近年来,OIS动物模型的制作方法有了较大进展,就该模型动物的选择、造模方法、各种模型优缺点的比较及其相关技术的展望进行总结.Ocular ischemic syndrome（OIS） is a disease seen in cardiology,ophthalmology,neurology and neurosurgery,which is characteristic by brain and ocular symptoms caused by carotid artery obstruction or stenosis.The diagnosis of OIS may be difficult because of its variable presentations and its concealed onset.What is more,its pathogenesis is not completely clear,and therefore its treating efficacy is dissatisfactory so far.The current study on OIS is focused on experimental research.So establishment of suitable animal model is important.Recently years,the creating method of OIS model made a great progress.The selection of model animals,extablishing methods of models and comparison of various models were summarized.

关 键 词：眼缺血综合征 颈动脉狭窄 颈动脉阻塞 疾病模型 动物 

分 类 号：R-332[医药卫生]