甲状旁腺激素对去卵巢大鼠骨质疏松牙周炎模型骨代谢的影响  

Effect of parathyroid hormone on bone metabolism of periodontitis model of postmenopausal osteoporosis of rat

作　　者：刘霞 邓凤英[2] 林志勇[2] 

机构地区：[1]山东省莒县人民医院,山东莒县276500 [2]山东大学附属省立医院,山东济南250021

出　　处：《临床口腔医学杂志》2014年第3期152-155,共4页Journal of Clinical Stomatology

基　　金：山东省科技发展项目(2010G0020226)

摘　　要：目的:观察甲状旁腺激素对去卵巢大鼠骨质疏松牙周炎模型骨代谢的影响。方法:4月龄健康雌性Wistar大鼠68只,随机分成4组,每组17只。即A组(健康对照组)、B组(伪手术组)、C组(去势牙周炎组),D组(去势牙周炎加甲状旁腺激素治疗组)。模型建立成功后,A、B、C组腹腔内注射等量的生理盐水,D组间歇性小剂量腹腔内注射等量甲状旁腺激素,隔日注射一次,用药8周。治疗后处死大鼠并通过CBCT扫描测定上颌骨密度,检测血清中钙(Ca2+)、磷(P3+)、碱性磷酸酶(ALP)水平。结果:治疗8周后,经CBCT图像测量,D组上颌骨密度较C组明显升高,差异有统计学意义(P<0.05),与A、B组上颌骨密度无明显差异,无统计学意义(P>0.05)。D组外周血中ALP水平高于A、B、C组(P<0.05),差异有统计学意义,各组血清钙、磷值没有明显改变(P>0.05)。结论:小剂量注射甲状旁腺激素能够增加骨密度并改善外周血中ALP的水平,促进牙槽骨的形成,对绝经期后牙周炎有明显的治疗作用。Objective： To investigate the influence of parathyroid hormone on bone metabolism of periodontitis model of postmenopausal osteoporosis of rat. Method： Choose 68 female Wistar rats which are healthy and 4 months old and divide them into four groups at random, each 17. Namely A （healthy control group）, B （sham group）, C （castration periodontitis）, D （castration periodontitis plus parathyroid hormone therapy group）. After a successful model, the A, B, C groups intraperi- toneal injection of normal saline, D group Intermittent intraperitoneal injection of the same amount of small doses of parathy- roid hormone, We make the intraperitoneal injection every other day to rats in each group, which continues for g weeks. After treatment, the rats were sacrificed and the maxillary bone density measured by CBCT scanning, detection of serum calcium （Ca2＋）, phosphorus （p3＋）, alkaline phosphatase （ALP） level. Result： After 8 weeks of treatment, through image measurement of CBCT, compared with group C, the bone density of alveoar bone significantly increased in group D. It was statistical sig- nificance （P 〈0.05）. Compared with group A and B, the bone density of alveolar bone in group D is similarly. It was not sta- tistical significance （P 〉0.05）. Group D in peripheral blood ALP levels greater than A, B, group C （P 〈0.05）, It was statisti- cal significance （P 〈0.05） .Seurm calcium and phosphorus values did not change significantly （P 〉0.05）. Conclusion： Small doses of parathyroid hormone injections can increase bone density and promote the level of ALP in peripheral blood in a certain extent, and it is conducive to osteogenesis. It has therapeutic effect on Postmenopausal periodontitis.

关 键 词：甲状旁腺激素 骨代谢 牙周炎 

分 类 号：R781.4[医药卫生—口腔医学]