血清CEA和CYFRA21-1对非小细胞肺癌的诊断价值  

作　　者：高文静[1] 黎灼滔[1] 钟方毅[1] 曾淑敏[1] 

机构地区：[1]广东省东莞市莞城医院检验科,广东523000

出　　处：《当代医学》2014年第8期111-112,共2页Contemporary Medicine

摘　　要：目的研究血清癌胚抗原(CEA)和细胞角蛋白19片段(CYFRA 21-1)对非小细胞肺癌的诊断价值。方法随机筛选广东省东莞市莞城医院住院患者血清标本,将35例非小细胞肺癌患者作为观察组,35例良性肺部疾病患者作为对照组,对两组患者的血清CEA和CYFRA 21-1进行电化学免疫检测。结果观察组患者的血清CEA和CYFRA 21-1两种指标的平均水平明显高于对照组,其中观察组CEA指标为(17.15±6.28)μg/L、CYFRA 21-1指标为(14.07±8.64)μg/L;对照组CEA指标为(3.51±1.17)μg/L、CYFRA 21-1指标为(2.61±2.184)μg/L。CYFRA 21-1对非小细胞肺癌的敏感性较高,而CEA对该病的特异性较高,两种指标联合诊断的敏感性明显增高,其中关于敏感度的检测,CEA检测为10例(28.57%),CYFRA 21-1检测为24例(68.57%),两者联合检测为29例(82.86%);关于特异性的检测,CEA检测为34例(97.14%),CYFRA 21-1检测为27例(77.14%),两者联合检测为21例(60.00%)差异均有统计学意义(均P<0.05)。结论 CEA和CYFRA 21-1联合检测用于非小细胞肺癌,具有较好的敏感性及特异性,可为临床诊断提供参考。Objective To explore the diagnostic value of carcinoembryonic antigen and Cytokeratin 19 fragment in serum for non-small cell lung cancer （NSCLC）. Methods 35 cases of patients with NSCLC were as observation group and 35 cases of person with benign lung disease were as control group. CEA and CYFRA 21-1 in serum of two groups were detected with ECLIA. Results CEA and CYFRA 21-1 in observation group was obviously higher than that in control group, CEA showed higher speciifcity and CYFRA 21-1 showed higher susceptibility for NSCLC, the CEA combined with CYFRA 21-1 showed higher susceptibility. The above-mentioned date showed signiifcant difference（P＆lt;0.05）. Conclusion The CEA combined with CYFRA 21-1 used for NSCLC are good susceptibility and speciifcity, can provide guidance for clinical diagnosis.

关 键 词：非小细胞肺癌 癌胚抗原(CEA) 细胞角蛋白19片段(CYFRA 21-1) 

分 类 号：R734.2[医药卫生—肿瘤]