肺癌患者血中部分常量元素的回顾性分析  

Levels of some major elements in patients with lung cancer: a retrospective analysis

作　　者：汪发九[1] 赵子恩[1] 闻剑波 江明君[1] 黄科峰[1] 葛建军[1] 戚赛春[1] 黄华奇 

机构地区：[1]宁波大学医学院附属鄞州人民医院胸外科,浙江省宁波市315100

出　　处：《中华全科医学》2014年第4期528-530,共3页Chinese Journal of General Practice

摘　　要：目的探讨血清中部分常量元素水平在肺癌患者中的检测价值。方法回顾性分析鄞州人民医院2012年1月1日—2013年10月30日259例病例资料,按临床诊断分为4组:腺癌组68位(占26.3%)、鳞癌组63位(占24.3%)、肺部感染组68位(占26.2%)及常规体检组60位(占23.2%),分别收集每位病例的血清无机磷、血清钙及血清镁水平数值。通过SPSS 19.0统计软件包统计分析其在肺癌中的价值。结果 4组病例中,性别、吸烟史及病例分组等一般资料无显著性差异。血清无机磷水平(单位:mmol/L):腺癌组(1.10±0.19)和鳞癌组(1.02±0.16)、腺癌(1.10±0.19)和常规体检组(1.19±0.20),差异有统计学意义(P<0.05);鳞癌组(1.02±0.16)和肺炎组(1.13±0.17)、鳞癌组(1.02±0.16)和常规体检组(1.19±0.20),差异有统计学意义(P<0.01);肺炎组(1.02±0.16)和常规体检组(1.19±0.20)、腺癌组(1.10±0.19)和肺炎组(1.13±0.17),差异均无统计学意义(P>0.05)。血总钙浓度和血镁浓度在不同病例组中差别无统计学意义(P>0.05)。ⅠA期肺癌与ⅡB期肺癌患者中血磷浓度比较差异有统计学意义(1.13±0.17)mmol/L vs(0.96±0.14)mmol/L(P=0.029),余各分期间血磷浓度差异无统计学意义(P>0.05);不同分期间血钙及血镁浓度差异均无统计学意义(P>0.05)。腺癌组男女性别中血磷浓度差异有统计学意义(1.01±0.20)mmol/L vs(1.12±0.10)mmol/L(P=0.026),余各分组间男女性别中血鳞浓度差异无统计学意义(P>0.05);不同分组间血钙及血镁浓度在男女性别中差异均无统计学意义(P>0.05)。结论血清无机磷水平在肺癌患者和非肺癌患者及健康病例中差别明显,血清钙及血清镁水平在肺癌患者及其他病例组中差别无显著性意义;血清磷水平可作为临床判断肺癌的一个辅助参考指标,但其临界值及其参考价值有多大有待进一步研究。Objective To investigate the value of levels of erum major elements in patients with lung cancer. Methods The clinical data of 259 cases of lung cancer January 1,2012 to October 30,2013 were analyzed retrospectively. The pa- tients were divided into four groups according to clinical diagnosis： adenocarcinoma group （68 cases ,26.3 % ）, squamous cell carcinoma group（ 63 cases, 24.3% ）, pneumonia group （68 cases, 26.2% ） and the routine physical examination group（60 cases ,23.2% ）. The levels of serum calcium,phosphate and magnesium were tested. The results were studied through statistical analysis by SPSS software version 19.0. Results Among the four groups, gender, smoking history and other general information had no significant differences. For serum inorganic phosphate （mmol/1） ： There were significant differences between adenocarcinoma group（ 1.10 -＋ 0.19 ） and squamous cell carcinoma group（ 1.02 ＋ 0.16） ,adenocarci- noma group（ 1. 10 ＋ 0. 19 ） and routine physical examination group （ 1. 19 ＋ 0.20 ）, squamous cell carcinoma group （ 1.02 ＋ 0.16） and pneumonia group （ 1.13 ＋ 0.17 ） , squamous cell carcinoma group （ 1.02 ＋ 0.16） and routine physical examination group （ 1.19 ＋ 0.20）. There were no significant differences between pneumonia group （ 1.02 _＋ 0.16） and rou- tine physical examination group（ 1.19 ＋ O. 20）, adenocarcinoma（ 1.10 -＋ 0. 19） and pneumonia group （1.13 0.17 ）. There were no significant differences in total serum calcium and serum magnesium value among four groups（ P 〉 0.05 ）. There was significant difference in serum inorganic phosphate（ 1.13 0.17） mmol/1 vs （0.96 0.14） mmol/1 between stage I A and I1 B＇lung cancer patients （P = 0.029）. There was no significant difference in total serum calcium and ser- um magnesium values among other stages（P 〉 0.05）. Serum inorganic phosphate was significant difference between gen- ders in adenocarcinoma group（ 1.01 ＋0.20） mmol/1 vs�

关 键 词：血清无机磷 血清钙 血清镁 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]