热激蛋白27及羰基还原酶1与肝癌的研究进展  

Research Progress in the Heat Shock Proteins 27 and Carbonyl Reductase 1 and Hepatocellular Carcinoma

作　　者：王莹[1] 袁志伟[1] 李伟霞[1] 申丽娟[1] 

机构地区：[1]昆明医学院海源学院,昆明650106

出　　处：《医学综述》2014年第4期607-610,共4页Medical Recapitulate

基　　金：云南省教育厅科学研究基金立项项目(2013Y608)

摘　　要：热激蛋白27(HSP27)是小热激蛋白亚家族中的一员,HSP27的高表达与乙型肝炎病毒(HBV)相关肝细胞癌(HCC)密切相关;且在正常肝、乙型肝炎、肝硬化、癌周肝硬化和HCC中,HSP27的表达有差异。羰基还原酶1(CBR1)属于短链脱氢还原酶家族,它在HCC中表达有差异,但在正常肝、乙型肝炎、肝硬化、癌周肝硬化中的表达目前无研究。肝癌早期发病隐匿,甲胎蛋白(AFP)作为肝癌早期诊断指标存在一定局限性。是否能将HSP27、CBR1与AFP三者联合检测HCC,提高肝癌早期诊断率或作为肝癌诊断标志物,有待进一步研究。Heat shock proteins 27 （HSP27） is a member of small heat shock proteins, and some studies have shown that expression of HSP27 is closely associated with hepatitis-B virus related HCC. And HSP27 expresses differently in normal liver, liver with hepatitis B, cirrhosis and paratumor cirrhosis and HCC. Carbonyl reductase 1 （CBR1） belongs to the short chain dehydrogenases/reductases family, CBR1 is expressed differently in HCC ,but so far there is no research in the expression level in normal liver,liver with hepatitis B, hepatitis B-related cirrhosis and paratumor cirrosis. Alpha fetoprotein（AFP） as early diagnostic indexes of HCC has some limitations. Whether combination of HSP27, CBR1 and AFP to detect HCC in order to improve early diagnosis rate of HCC, or to use them as the potential biomarkers for HCC, still needs further studies.

关 键 词：肝细胞癌 热激蛋白27 羰基还原酶1 

分 类 号：R364[医药卫生—病理学]