An H-phosphonate strategy for the synthesis of 2',3'-dideoxynucleoside triphosphates and homodinucleotides  

作　　者：Qi Sun Si Liu Jian Sun Shan-Shan Gong 

机构地区：[1]Jiangxi Key Laboratory of Organic Chemistry,Jiangxi Science and Technology Normal University

出　　处：《Chinese Chemical Letters》2014年第3期427-430,共4页中国化学快报（英文版）

基　　金：National Natural Science Foundation of China (Nos. 21002041 and 21262014);Natural Science Foundation of Jiangxi Province (No. 20114BAB203008);Project of the Science Funds of Jiangxi Education Office (No. GJJ12589);Key Project of Chinese Ministry of Education (No. 212092);Scientific Research Foundation of Chinese Ministry of Human Resources and Social Security for Returned Chinese Scholars for financial support

摘　　要：The triphosphates and homodinucleotides of AZT and d4T have been efficiently synthesized from the corresponding nucleoside 5-H-phosphonate monoesters via the reactive pyridinium phosphoramidate intermediates.The triphosphates and homodinucleotides of AZT and d4T have been efficiently synthesized from the corresponding nucleoside 5-H-phosphonate monoesters via the reactive pyridinium phosphoramidate intermediates.

关 键 词：2＇ 3＇-DideoxynucleosidesNucleoside triphosphateHomodinucleotideH-Phosphonate 

分 类 号：R914[医药卫生—药物化学]