异甘草酸镁治疗急性药物性肝损伤临床疗效观察  

CLINICAL EFFECT ON THE TREATMENT OF ACUTE DRUG-INDUCED LIVER INJURY WITH MAGNESIUM ISOGLYCYRRHIZINATE

作　　者：李书良[1] 崔小玲[1] 姬文燕[1] 李晶[1] 

机构地区：[1]焦作煤业集团中央医院消化科,河南省焦作市454000

出　　处：《中国煤炭工业医学杂志》2014年第3期368-370,共3页Chinese Journal of Coal Industry Medicine

摘　　要：目的观察异甘草酸镁治疗急性药物性肝损伤的临床效果。方法收集78例急性药物性肝损伤患者,随机分为对照组和治疗组,对照组36例给予常规保肝药物治疗,治疗组42例在常规保肝治疗基础上加用异甘草酸镁治疗,疗程均为4周。观察治疗前后临床症状、肝功能变化和不良反应情况。结果治疗后二组比较,临床症状改善方面差异无统计学意义;肝功能指标ALT、AST、TBil、ALP差异均有统计学意义,治疗组总有效率为95.24%,对照组为80.56%,二组差异有统计学意义;不良反应二组差异无统计学意义。结论异甘草酸镁对急性药物性肝损伤疗效确切,不良反应少,值得临床应用。Objective To observe the clinical effects on the treatment of acute drug-induced liver injury with magnesium isoglycyrrhizinate. Methods There were 78 patients with acute drug- induced liver injury ran-domly divided into control group and treatment group. The control group （36 cases） was given routine liver drug treatment for 4 weeks, the treatment group （42 cases） was given magnesium isoglyeyrrhiz- inate on the basis of routine liver treatment for 4 weeks. Changes were observed before and after treat-ment of clinical symptoms, liver function and adverse reactions. Results The results in the two groups were compared after treatment. There was no significant difference in the clinical symptoms improved. Liver function index such as ALT, AST, TBil, ALP all had significant difference. The ef-fective rate in the treatment group was 95.24% （40/42） and in the control group was 80.56% （29/ 36）, showing significant difference （X^2 = 7. 41,P〈0. 05）. There was no significant difference in ad-verse reactions between the two groups. Conclusion Magnesium isoglycyrrhizinate is exactly effective and less side effects for treatmenf of acute drug- induced liver injury. It is worthy of clinical applica-tion.

关 键 词：异甘草酸镁 急性药物性肝损伤 药物治疗 

分 类 号：R575[医药卫生—消化系统]