新型抗癫痫药物治疗儿童癫痫的研究进展  

Progress of New Antiepileptic Drugs in the Treatment of Epilepsy in Children

作　　者：刘砚韬[1,2] 张伶俐[1,2] 黄亮[1,2] 梁毅 曾力楠[1,2] 

机构地区：[1]四川大学华西第二医院药学部,循证药学中心 [2]四川大学华西第二医院出生缺陷与相关妇儿疾病教育部重点实验室,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2014年第1期90-95,共6页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：国家自然科学基金(81373381)~~

摘　　要：癫痫是小儿神经系统的常见疾病,目前药物治疗仍是首选方法。新型抗癫痫药物(AED)具有抗癫痫谱广、不良反应少,耐受性和安全性较传统AED高等优点,为临床治疗儿童癫痫提供了更多的选择。但由于全球性的儿童临床试验缺乏,导致包括AED在内的大多数药物缺少在癫痫患儿中使用的临床疗效和安全性数据,而直接根据成年人药物临床试验结果进行简单剂量折算后使用,忽略了儿童与成年人之间的区别,新型AED在儿童使用中仍存在此问题。近年来,许多研究均提出对于新型AED的安全性和有效性应以循证医学的理念进行指南制定,特别是针对儿童这一特殊人群。作者拟对常见新型AED治疗儿童癫痫的进展和循证医学证据,进行综述如下。Epilepsy is one of the most common pediatric neurological diseases, and antiepileptic drug therapy is the preferred method at present. The new antiepileptic drugs （AED） with the advantages of wide spectrum, less adverse reaction, high tolerance and safety than traditional AED, have given physicians new options for the treatment of children with epilepsy. However, due to the lack of global clinical trials in children, most of the drugs, including AED, are lack of clinical efficacy and safety data for children, and just use in children with a dosage of a simple conversion from adult dose, witch neglected children distinction between adults. Recently, several studies suggested evidence-based guidelines for the efficacy and tolerability of the new AED and offered expert opinions, including those concerned with pediatric patients, to facilitate more reasonable selection of the new AED. In this article, we review the progress and evidence-based evidence of common new AED in treatment of epilepsy in children and summarized below.

关 键 词：癫痫 抗惊厥药 治疗 儿童 

分 类 号：R742.1[医药卫生—神经病学与精神病学]