帕罗西汀片合并经颅微电流刺激疗法治疗焦虑障碍  

A Comparative Study of Anxiety Disorders Treatment with Paroxetine Associated with Cranial Electrotherapy Stimulation Therapy

作　　者：卢玲[1] 胡君[1] 

机构地区：[1]沈阳市精神卫生中心,辽宁沈阳110168

出　　处：《中国医学创新》2014年第8期80-82,共3页Medical Innovation of China

摘　　要：目的:探讨经颅微电流刺激疗法(CES)对焦虑障碍治疗辅助功效。方法:选取符合CCMD-3焦虑障碍诊断标准并愿意参加本项研究的120例患者,按照随机数字表法分为研究组和对照组,每组60例。除研究组进行6周(共42次)经颅微电流刺激疗法治疗外,两组同时均给予治疗剂量帕罗西汀治疗6周。治疗前后对两组均采用汉密尔顿焦虑量表(HAMA)、临床疗效总评量表-病情严重程度(CGI-SI)评定、WHO生存质量测定简表(WHOQOL-BREF)评定焦虑治疗效果及生活质量改善程度。结果:研究组显效率为76.67%,对照组为53.33%,两组比较差异有统计学意义(P<0.05)。两组HAMA和CGI-SI评分治疗后均较治疗前显著降低,与治疗前比较差异有统计学意义(P<0.05);治疗6周时,研究组HAMA和CGI-SI评分下降较对照组更为显著,两组比较差异均有统计学意义(P<0.05)。两组治疗后生存质量4个领域项目评分均明显提高,与治疗前比较差异均有统计学意义(P<0.05);治疗6周时,研究组生理领域评分增加更为显著,两组比较差异均有统计学意义(P<0.05)。结论:帕罗西汀合并经颅微电流刺激疗法优于单独应用帕罗西汀治疗焦虑障碍。Objective：To explore the assistant effect of cranial electrotherapy stimulation therapy in the treatment of anxiety disorders.Method：One hundred and twenty patients with anxiety disorder were randomly divided into the study group and the control group,each group of 60 cases. All of them were given treatment of paroxetine for 6 weeks,besides,patients in study group accepted 42 times cranial electrotherapy stimulation therapy in 6 weeks. The efficacy was assessed with the Hamilton anxiety scale（HAMA）and clinical global impression scale（CGI-SI）,quality of the patients of life was assessed with the WHO quality of life questionnaire（WHOQOL-BREF）before and after treatment.Result：After 6 weeks of treatment ,the significant efficacy rates of the study group and the control group were 76.67% and 53.33% respectively,and the difference between the two groups were statistically significant（P〈0.05）. The scores of HAMA and CGI in two groups after treatment were significantly decreased than before treatment（P〈0.05）. The scores of HAMA and CGI in the study group was reduced more significantly than the control group at 6th weekend after treatment（P〈0.05）. The score in four areas of quality of life were significantly improved after treatment in the two groups（P〈0.05）. The physiological domain score in study group was increased significantly（P〈0.05）.Conclusion：Treating anxiety disorders with paroxetine associated with cranial electrotherapy stimulation therapy is better than only with paroxetine.

关 键 词：焦虑障碍 经颅微电流刺激疗法 帕罗西汀 

分 类 号：R749.72[医药卫生—神经病学与精神病学]